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The effect of Integrated Orthodontic and Periodontal Regenerative Therapies on Periodontal Health and Inflammatory Responses
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MR Abdulkareem *    |
| 1.Department of Dentistry, Alsalam University College, Baghdad, Iraq. , muntasser.r.abdulkareem@alsalam.edu.iq |
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Abstract: (541 Views) |
Background and Objective: Time-based diseases such as periodontitis usually occur due to multifactorial causative agents and the progressive destruction of the tissues with a recurrent nature. The present study aims to evaluate the effectiveness of periodontal regenerative therapy along with orthodontic treatment in improving periodontal health and reducing inflammation activation.
Methods: This prospective cross-sectional study was conducted on 120 patients who visited a private dental clinic in Baghdad from May 2022 to May 2023. Of these patients, 60 patients were randomly assigned into two groups: 30 patients received standard treatment without medical intervention and the other group received a combination of daily periodontal care and regenerative treatment. The clinical indices, including gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), plaque index (PLI), clinical attachment level (CAL), and subgingival microbial composition were assessed. The levels of inflammatory mediators such as interferon-alpha (IFN-a), C-reactive protein (CRP), interleukin-17 (IL-17), and interleukin-33 (IL-33) were studied in the gingival crevicular fluid.
Findings: In experimental group, 94% had successful treatment outcome, while 78% recorded a successful outcome in the control group (χ²=5.316, p<0.05). There was a significant reduction in GI (1.18±0.27 vs 0.33±0.09), PLI (1.78±0.35 vs 0.84±0.20), PD (5.42±0.51vs 2.78±0.36), SBI (2.79±0.41 vs 1.25±0.28), CAL (3.15±0.45 Vs 2.02±0.24), and the percentages of P. gingivalis and Aggregatibacter actinomycetemcomitans in the experimental group as compared to the control group (p<0.05). Additionally, the inflammatory mediator levels decreased considerably.
Conclusion: The results showed periodontal procedures, coinciding with the orthodontic procedures, enabled significant enhancement and minimal inflammatory reaction, demonstrating a high success rate and clinical efficacy in treating periodontitis. |
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| Keywords: Periodontitis, Orthodontic Treatment, Periodontal Tissue Regeneration, Inflammatory Mediators, Clinical Efficacy. |
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Full-Text [PDF 315 kb]
(92 Downloads)
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Type of Study: Research |
Subject:
Restorative Dentistry
Received: 2024/11/24 | Accepted: 2025/01/18 | Published: 2025/05/3
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