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Study of OGG1 rs1052133C>G polymorphism in Thyroid Cancer Susceptibility in Northwest of Iran
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N Pouladi *    , S Didevar Tabrizi , R Ravanbakhsh |
| 1.Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, I.R.Iran. , srna52@gmail.com |
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Abstract: (172 Views) |
Background and Objective: Thyroid cancer is the most common endocrine malignancy worldwide. Genetic studies have focused on the impact of polymorphisms on genes involved in DNA repair and cancer risk of susceptibility to cancer. The OGG1 is a key enzyme in the DNA repair pathway. Research shows that OGG1 rs1052133C>G is associated with an increased risk of susceptibility to various cancers. The main objective of this study was to investigate the association of the mentioned polymorphism with risk of thyroid cancer susceptibility in the northwestern region of Iran.
Methods: In this case-control study, 104 patients with thyroid cancer (confirmation of cancerous thyroid tissue by a pathologist) and 166 control individuals (healthy people without any cancer in themselves and first-degree relatives) were selected. Blood samples were collected and their DNA was extracted using saturated salt method. Genotypes of OGG1 were identified and investigated using Tetra-ARMS PCR method. Statistical analysis was performed using Chi test and SPSS software version 26.
Findings: In this study, the frequency of CC, CG and GG genotypes in the patient group was 53.84%, 38.46% and 7.69%, respectively and in the control group and 51.2%, 41.56% and 7.22%, respectively. The frequencies of allele C and G were 73.06% and 26.92% in the case and 71.98% and 28.01% in the control group, respectively. Based on the results, no significant difference was observed between the case and control group in different models of inheritance.
Conclusion: The results showed that there was no association between rs1052133C> G polymorphism of OGG1 gene and the risk of thyroid cancer in the northwestern region of Iran. |
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| Keywords: Polymorphism, OGG1 Gene, Thyroid Cancer, rs1052133. |
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Type of Study: Case-Control |
Subject:
Genetics, Cell and Molecular Biology
Received: 2023/12/25 | Accepted: 2024/08/6
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