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:: Volume 18, Issue 8 (8-2016) ::
J Babol Univ Med Sci. 2016; Volume 18 Back to browse issues page
Comparison of the Serum Total Bile Acids and Cholesterol Levels in Breast Cancer Patients with Control Group
S Fadaeipuor , Z Babaei , H Parsian * , A Motevalizadeh Ardekani , N Nikbakhsh
Cancer Research Center, Institute of Health, Babol University of Medical Sciences, I.R.Iran , hadiparsian@yahoo.com
Abstract:   (6140 Views)

BACKGROUND AND OBJECTIVE: Identification of breast cancer risk factors is very important. Cholesterol by acting on tumor cells is considered as one of the risk factors for breast cancer. The conversion of cholesterol to bile acids is one of the major mechanisms of cholesterol excretion from body. In this study, total bile acids and cholesterol concentrations were evaluated in breast cancer patients.

METHODS: In this case-control study, 109 of patients who breast cancer was confirmed by pathological examination and 109 healthy subjects who had normal physical exam and negative mammograms to rule out breast cancer were studied. Fasting serum total bile acids and cholesterol levels were measured enzymatically and then the data were analyzed.

FINDINGS: The mean of total bile acids in breast cancer patients and control group were 11.67±0.92 and 13.36±0.81 µmol/l, respectively (p<0.05). Mean of cholesterol levels in breast cancer patients was 316.98±15.35 mg/dl and control group was 212.08±5.79 mg/dl (p<0.001).

CONCLUSION: According to the results, it appears that lower amounts of body cholesterol are converted to bile acids in breast cancer patients.

Keywords: Breast Cancer, Total Bile Acids, Cholesterol.
Full-Text [PDF 199 kb]   (1976 Downloads)    
Type of Study: Case-Control | Subject: Biochemical
Received: 2015/12/30 | Accepted: 2016/08/14 | Published: 2016/08/30
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Fadaeipuor S, Babaei Z, Parsian H, Motevalizadeh Ardekani A, Nikbakhsh N. Comparison of the Serum Total Bile Acids and Cholesterol Levels in Breast Cancer Patients with Control Group. J Babol Univ Med Sci 2016; 18 (8) :48-53
URL: http://jbums.org/article-1-5880-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 8 (8-2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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