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Analysis of Association between IL-17 gene rs2275913 Single Nucleotide Polymorphism and Chronic Hepatitis B Infection
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H Tayefinasrabadi   , SR Mohebbi * , P Azimzadeh , B Hatami , Sh Kazemian , M Saeedi Niasar , A Sharifian , M Zali |
| Gastroenterology and Liver Diseases Research Center, Gastroenterology and Liver Diseases Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran , sr.mohebbi@sbmu.ac.ir |
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Abstract: (4707 Views) |
BACKGROUND AND OBJECTIVE: Hepatitis B disease is one of the main causes of inflammation and liver damage that can lead to chronic hepatitis B virus infection. Single nucleotide polymorphism in the cytokines gene can affect the host immune response. Interleukin 17 produced by Thelper17 cells has been shown to play a role in immune function in infectious and inflammatory diseases. This study was conducted to investigate the association between polymorphism in IL-17 gene (rs2275913) and chronic hepatitis B infection.
METHODS: This case-control study was performed on 130 chronic patients as a case group and 130 healthy individuals as control. Patients with positive result of ELISA test for HBsAg and Anti-HBc Ab and control subjects with negative result of this test were enrolled. PCR-RFLP was used to genotype extracted DNA from blood samples.
FINDINGS: The genotype frequencies of rs2275913 did not show significant difference between patients and control groups. Distribution of genotypes inpatients were, 40.8% GG, 41.5% AG, 17.7% AA and in control group were, 42.3% GG, 45.4% AG, 12.3% GG (p=0.469).
CONCLUSION: The results of study showed no relation between IL-17 gene polymorphism rs2275913 and chronic HBV. |
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| Keywords: Hepatitis B virus, Interleukin-17, Single Nucleotide Polymorphism |
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Full-Text [PDF 223 kb]
(1496 Downloads)
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Type of Study: Case-Control |
Subject:
Virology
Received: 2017/08/1 | Accepted: 2018/01/6 | Published: 2018/01/24
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