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:: Volume 19, Issue 9 (9-2017) ::
JBUMS 2017, 19(9): 32-38 Back to browse issues page
A Comparison of the Therapeutic Effects of Metformin, Pioglitazone and Vitamin E in Patients with Non-Alcoholic Fatty Liver
K Shahebrahimi , Sh Zulnoorian , A Almasi , A Sharifi , AA Keshvarz , N Farshchian
Department of Nursing, Faculty of Nahavand Paramedical, Hamadan University of Medical Sciences, Hamadan, I.R.Iran , a.sharifi@umsha.ac.ir
Abstract:   (1142 Views)

BACKGROUND AND OBJECTIVE: Non-alcoholic Fatty Liver Disease (NAFLD) is specified by changes in fat in the liver, with or without inflammation. The disease is the hepatic manifestation of metabolic syndrome. Since a different medicinal treatment has been introduced, this study was conducted to compare the therapeutic effects of metformin, pioglitazone and vitamin E in treatment of these patients.
METHODS: In this single-blind randomized clinical trial, 93 patients with the diagnosis of NAFLD who referred to Imam Reza Hospital in Kermanshah were randomly divided into three groups (n = 31). Then, the first group received two gr/day metformin, the second group received 30 mg/day pioglitazone and the third group received 800 IU/day vitamin E for 12 weeks. LFTs, BMI, HOMA-IR, FBS, and serum insulin levels were measured before and after the treatment course (IRCT: 2016010411991N3).
FINDINGS: There was no significant difference between the groups in terms of distribution of sex, mean age, LFT and HOMA-IR before treatment. The mean difference in severity of NAFLD before or after the treatment was metformin (1.06 ± 0.63), pioglitazone (1.195±0.75) and vitamin E (0.77±0.62), which was statistically significant (p<0.05). In addition, serum insulin levels (p<0.01) and HOMA-IR (p<0.05) were significant between the groups; pioglitazone showed highest effect on reducing the severity of NAFLD, serum insulin levels, and HOMA-IR. Metformin and vitamin E were next in line, respectively.
CONCLUSION: Based on the results of this study, pioglitazone is more effective than metformin and vitamin E both in reducing the severity of NAFLD and in lowering LFT and serum insulin levels.

Keywords: Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome, Metformin, Pioglitazone, Vitamin E
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Type of Study: Interventional | Subject: e
Received: 2017/04/25 | Accepted: 2017/09/4 | Published: 2017/09/17
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Shahebrahimi K, Zulnoorian S, Almasi A, Sharifi A, Keshvarz A, Farshchian N. A Comparison of the Therapeutic Effects of Metformin, Pioglitazone and Vitamin E in Patients with Non-Alcoholic Fatty Liver. JBUMS. 2017; 19 (9) :32-38
URL: http://jbums.org/article-1-6759-en.html


Volume 19, Issue 9 (9-2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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