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Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures
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S Baradaran    , M Ghasemi-Kasman * , A Ebrahimpour , SR Ahmadian , M Pouramir |
| Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran , maryam.ghasemi65@gmail.com |
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Abstract: (5459 Views) |
Background and objective: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including anti-oxidant and anti-inflammatory effects. In this study, the effects of hesperetin on seizures behavior and its function on total antioxidant capacity and lipid peroxidation has been investigated in pentylenetetrazol (PTZ)-induced seizures model.
Materials and methods: In this experimental study, thirty-five mice were divided into 5 experimental groups as control, saline and hesperetin at doses of 10, 20 or 50 mg/kg. Animals received orally the related interventions for 7 days. On day 7, 30 minutes after oral gavage, convulsion was induced by single intraperitoneal (i.p.) injection of PTZ at dose of 60 mg/kg. After recording of convulsion behaviors including latency to myoclonic jerks, latency and duration of generalized tonic-clonic seizures, time to death, measuring of Ferric Reducing Antioxidant Power (FRAP) and Thiobarbituric acid reactive substances (TBARS) carried out in hippocampus tissues.
Findings: Pretreatment with hesperetin at dose of 50 mg/kg significantly increased the latency of myoclonic jerks (hesperetin 50: P=0.0323) and generalized tonic-clonic seizures (hesperetin 10: P= 0.0003, hesperetin 20: 0.0017, hesperetin 50: P=0.0040). Hesperetin application at dose of 10 mg/kg significantly reduced the levels of TBARS compared to control group. Any significant difference in FRAP levels was not observed between different experimental groups.
Conclusion: The results of study indicate that hesperetin might be effective as supplementary treatment in epilepsy disorder. |
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| Keywords: Hesperetin, Convulsion, Pentylenetetrazol |
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Full-Text [PDF 385 kb]
(1251 Downloads)
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Type of Study: Experimental |
Subject:
Physiology
Received: 2018/08/5 | Accepted: 2018/10/21 | Published: 2018/10/21
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