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The Effect of Chrysin Nanoparticles in Preventing the Growth of Mcf-7 Cancer Cells
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M Norouzi *    , SL Rezazadeh , AA Moghadamnia , N Bahramifar , L Barari , S Kazemi |
| Department of Chemistry, Payame Noor University, Tehran, I.R.Iran , m.norozi@gmail.com |
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Abstract: (4242 Views) |
BACKGROUND AND OBJECTIVE: Chrysin is a natural and biologically active compound extracted from plants, honey and propolis. Since chrysin has pharmacological activities such as antioxidant, anti-inflammatory and anti-cancer properties, this study was conducted to compare the effect of chrysin and its nanoparticle on breast cancer cells (Michigan Cancer Foundation-7).
METHODS: In this study, chrysin nanoparticles were prepared using chitosan, and then the prepared nanoparticles were dissolved in water, and the cytotoxic effects of 20, 40 and 80 μM chrysin and chrysin dissolved in dimethyl sulfoxide (at the same concentrations) on MCF7 cells were investigated. Cell viability was measured using MTT assay after 24, 48 and 72 hours, and was compared with viability of the control samples.
FINDINGS: The results of this study showed that chrysin and chrysin nanoparticles prevented the growth and proliferation of MCF7 cell line. These effects depend on the concentration of chrysin and its nanoparticles, and it has been shown that the effect of chrysin nanoparticle on cells at a concentration of 40 μM in 72 hours is significant with p<0.001 while it is significant with p<0.01 at the same concentration in 24 and 48 hours. The IC50 value of chrysin nanoparticle was approximately 40 μM.
CONCLUSION: The results of the study showed that the chrysin nanoparticle exhibits anti-proliferative activity in breast cancer cells in the laboratory and its effect is greater than that of chrysin. |
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| Keywords: Chrysin, Nanoparticle, MCF7, MTT, Breast Cancer. |
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Full-Text [PDF 376 kb]
(1717 Downloads)
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Type of Study: Research |
Subject:
Pharmacology
Received: 2018/04/28 | Accepted: 2018/10/23 | Published: 2018/11/10
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