Comparison of Capparis spinosa L. Seeds and Morus alba L. Leaves Extracts with Glibenclamide on Blood Glucose and Lipids in Diabetic Rats
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Pari Nazari * , Sohila Ebrahimi , Javad Cheraqi , Alireza Rangin ![](./files/0allsites/images/pubmed20.png) |
, nazp14st@gmail.com |
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Abstract: (8037 Views) |
BACKGROUND AND OBJECTIVE: Since Capparis spinosa and Morus alba traditionally have been used to
treat some
diseases, this study investigated the anti-diabetic and anti-hyperlipidemic effects of hydroalcoholic C.spinosa seeds and M.alba aqueous leaves xtract separately and in combined on blood glucose and lipids in diabetic. METHODS: In
this experimental study, 60 rats weighting 200-220 gr were
divided into 6 groups of 10 each: diabetic control group, treated diabetic groups with different concentrations of 200, 400 and 800 mg/kgbw with the
extracts of these two plants separately and in combination and treated diabetic group with Glibenclamide. Streptozotocin was used to induce diabetes. The extracts of C.spinosa and M.alba with doses of 200, 400 and 800 mg/kgbw
and glibenclamide with 600 doses
were fed
them separately and in combination. Taking blood from rats was done in fasting condition and blood glucose level was determined with enzym and triglyceride, cholesterol and lipoproteins method using Pars Azmon Kits. FINDINGS: The extract of M.alba
leaves had the best effect on reducing the blood glucose level with dose of 200mg/kg (92/26±16mg/dl) (p<0/01). 800 mg/kg concentration reduced cholesterol (74/8±16mg/dl), triglyceride (25/7±12 mg/dl) and LDL (10/2±1/5 mg/dl) (p<0/05). 400
mg/kg dose of M.alba extract increased the amount of
HDL (63/2±2/5mg/dl, p<0/05). The
extract of C.spinosa
with 200 mg/kg concentration had
the best effect on reducing the blood glucose (117/1±16 mg/dl, p<0/01) and
triglyceride (82/02±14/2 mg/dl, p<0/05) levels. This extract with 800mg/kg
concentration declined cholesterol (83/3±1mg/dl)
and LDL (9/7±2/1mg/dl) (p<0/05). Its
concentration of 400mg/kg increased the amount of
HDL (74/8±19/7). The combination
of two extracts with dose of 200 mg/kg reduced blood glucose (106/4±24) and triglyceride (73/23±18mg/dl) (p<0/05).
800 mg/kg of this combination reduced cholesterol
(69/4±2/4mg/dl) and LDL (14/4±3/9 mg/dl)
(p<0/05). 400 mg/kg of it increased HDL
(60/5±17mg/dl, p<0/01). CONCLUSION: The
results showed that there are some effective
materials in C.spinosa and
M.alba extracts which have the
capability of reducing blood glucose and
lipids. |
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Keywords: KEY WORDS: Diabates mellitus, Blood glucose, Lipid, Capparis spinosa, Morus alba. |
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Full-Text [PDF 315 kb]
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Type of Study: Experimental |
Subject:
Physiology Received: 2014/05/22 | Accepted: 2014/09/14 | Published: 2014/11/19
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