1 1561-4107 Journal of Babol University Of Medical Sciences 3089 Biochemical NULL 1 12 2007 9 5 7 13 02 06 2014 NULL
2497 Biochemical THE EFFECT OF GABAPENTIN ON ACETIC ACID INDUCED VISCERAL PAIN: INVOLVMENT OF MU OPIOID & GABAa RECEPTORS Meimandi M Sepehri, GH.R Mobasher M Parhizgar A 1 12 2007 9 5 14 19 02 06 2014 BACKGROUND AND OBJECTIVES: Gabapentin is an anticonvulsant drug which also possesses antinociceptive effect in wide spectrum kind of pain, like neuropathic pain. However its effectiveness on visceral pain is not elucidated yet. This study was performed to investigate the effect of gabapentin on acetic acid induced visceral pain in mice and also to evaluate probable involvement of Mu opioid and gabaergic receptors on the gabapentin antinociception.METHODS: In this experimental study, adult male mice weighing 30g were divided into thirteen subsequent groups. In control group, animals received normal saline 40 min before intraperitoneal (ip) injections of 0.6% acetic acid (4ml/kg) and then visceral contractions were measured for 90 min. The mice were given gabapentin (25, 50, 100, & 200 mg/kg/i.p.) and then the visceral contractions were measured in the same way as controls. Other groups were given either naloxone as mu opiod antagonist (4mg/kg/i.p.), or the antagonists of GABAA receptors, picrotoxin (0.75, 1; 1.5 mg/kg/i.p.) or bicuculline (0.5, 0.75, 1.5, & 2 mg/kg/i.p.) 10 min prior to the most effective dose of gabapentin. Thereafter visceral contractions were counted similar to control group.FINDINGS: Gabapentin markedly reduced acetic acid induced visceral pain in mice and dose of 50mg/kg of gabapentin was the most effective (p<0.01). Visceral contractions following naloxone administration (4mg/kg/i.p) 10 min prior to gabapentin was not significantly different from gabapentin group. However, picrotoxin and bicuculline antagonized the inhibitory effect of gabapentin on visceral contractions in a dose dependent manner, i.e. the dose of 1.5 mg/kg/ip of picrotoxin or more like as the dose of 2mg/kg/ip of bicuculline increased the mean number of visceral contractions in comparison with gabapentin group which received 50mg/kg/ip (p<0.05). CONCLUSION: The results showed that picrotoxin and bicuculline are able to antagonize the antinociceptive effect of gabapentin on actic acid induced visceral pain in dose dependent manner. It is implicated that the effect of gabapentin on visceral pain may be mediated partly through the GABAA receptors. 2498 Biochemical COMPARISON OF PROTEIN VALUE OF CERELAC WITH HOMEMADE FOOD (VETCH AND RICE) Asemi Z Taghizade M 1 12 2007 9 5 20 26 02 06 2014 BACKGROUND AND OBJECTIVES: Evaluation of the quality of food proteins have a great importance because of biological and economical impacts. Among existing methods, NPR (net protein ratio), TPD (true protein digestibility) and PER (protein efficiency ratio) have been suggested as appropriate methods to determine the quality of proteins. This study was conducted to compare protein value of cerelac with homemade food (vetch and rice) in rats.METHODS: This experimental study was conducted on 64 male wistar rats, aged 21 days under 8 diets in 8 groups including: cases (cerelac and homemade food), standard (casein+methionine) and basal (protein free), 4 diets in order to determine NPR and PER and cases, standard and basal, 4 diets to study TPD. Period of study for NPR, TPD and PER were 14, 5 and 28 days. FINDINGS: NPR was 4.3±0.4, 4.3±0.9 and 4.2±0.4, TPD was 92.8±4, 87±8 and 81.1±6.1 and PER was 3±0.2, 2.5±0.4 and 2.7±0.6 for standard, cerelac and homemade food groups, respectively. Difference in NPR, TPD and PER between two baby food groups was not significant. CONCLUSION: The results showed that NPR and TPD for homemade food were nearly equal cerelac and PER was higher than cerelac. 3091 Biochemical NULL 1 12 2007 9 5 27 31 02 06 2014 NULL 3094 Biochemical NULL 1 12 2007 9 5 32 36 02 06 2014 NULL 2499 Biochemical EFFICACY OF DACRYOCYSTORHINOSTOMY WITH CATHETER INSERTION OR BODKIN TUBE IN THE TREATMENT OF NASOLACRIMAL OBSTRUCTION Mikaniki, E Rasolinejad SA 1 12 2007 9 5 37 40 02 06 2014 BACKGROUND AND OBJECTIVES: Treatment of nasolacrimal obstruction is controversial. The purpose of this study was to compare the efficacy of dacryocystorhinostomy (DCR) with catheter intubation or bodkin tube in the treatment of nasolacrimal obstruction. METHODS: This Quasi- experimental study was conducted on patients with lacrimal obstruction who referred to the department of ophthalmology, Babol Medical University from 1999 to 2006. All cases were treated with DCR with intubation or Bodkin tube. Catheter or bodkin tube was drawn out 3 weeks and 4 months, respectively. After treatment all cases were followed at a 3 month interval for one year. Success rates in these two treated groups were compared. FINDINGS: In group DCR with catheter, 79 cases (50 females, 29 males) with the mean age of 34 ± 16 years and in group bodkin tube, 103 cases (50 females, 53 males) with the mean age of 35± 0.5 years were treated. The mean age and sex distribution among these two treated groups were equal (p=0.052). The success rate with DCR with catheter intubation was 96.2% and DCR with Bodkin tube was 99.1%. Significant difference was not seen between two groups in treatment failure.CONCLUSION: Dacryocystorhinostomy with catheter intubation or bodkin tube both have the same efficacy for treatment of nasolacrimal obstruction. However the efficacy of dacryocystorhinostomy with Bodkin tube is associated with lower recurrence rate but the difference was not significant. 2500 Biochemical EVALUATION OF THE APICAL LEAKAGE OF SURROUND ENDODONTIC IMPLANTS CEMENTED WITH MTA IN VITRO Moradi S Rohani A Akbari M 1 12 2007 9 5 41 44 02 06 2014 BACKGROUND AND OBJECTIVES: Endodontic implants are metalic extension of a tooth root using a post prepared for maintaining teeth that must be extracted. One of the most important factors of implant failures is improper apical seal between implant and end of root. The purpose of this study was to evaluate the effect of MTA (mineral trioxide aggregate) on apical seal surround endodontic implants.METHODS: In this experimental in-vitro study twenty eight freshly extracted human maxillary central incisors and canines were used. After cleaning, all teeth were cast in putty and then removed from cast and cut from middle one third of the root. Access cavity was made and canals enlarged with hand instrumentation and piezoreamer drills in such manner that drills were extruded from apex. The teeth were replaced in the cast and buccal portion of the cast was removed. Teeth were randomly divided into two groups. In group A implants were placed at canals through access cavity and cement with glass ionomer cement. In group B before implant placement, MTA packed at the end of the canals then a tract were made within them. After MTA setting, implants were placed at the canals like group A and cemented with glass ionomer cement. Access cavity sealed and all surfaces of the teeth were covered with two layer of nail varnish except apical 2 millimeters. Dye penetration was measured using foshin solution. After splitting the teeth longitudinally, dye penetration was measured by stereomicroscope. FINDINGS: Average of dye penetration for group A and B is 0.32 and 0.22mm, respectively. The average of dye penetration in group A was significantly higher than group B (p<0.05).CONCLUSION: Application of MTA improves apical seal surround endodontic implants, thus increase successful rate of it. 2501 Biochemical INFLUENCE OF CIGARETTE SMOKING ON THE OCCURRENCE OF COATED AND HAIRY TONGUE Babaee N Motalebnejad M Ghorbanpour M 1 12 2007 9 5 45 49 02 06 2014 BACKGROUND AND OBJECTIVES: One of the problems that the developed societies are faced to it is smoking. The oral mucosa and the tongue are also exposed to the tobacco products and smoke. Coated and hairy tongue is the lesions that can be developed due to the use of tobacco. The aim of this study was to determine the influence of the amount of cigarette smoking on the occurrence of two lesions called coated and hairy tongue.METHODS: This cross sectional study was done on 534 subjects (262 non-smokers, 136 smokers and 136 heavy smokers) of the male patients who were referred to the oral disease section of Babol dental school during 2005 and 2006. Patients who didn receive antibiotic, oxidizing mouthwashes, antiacids, alcohol and coffee during the past month and didn have removable prosthesis and the history of systemic disease were included in the study. The patients have been matched in three groups according to the amount of cigarette consumption.FINDINGS: The frequency of coated tongue in the three groups non-smokers, smokers and heavy smokers were 26 (9.9%), 50 (36.8%) and 70 (51.5%), respectively and also the frequency of hairy tongue were 1 (0.4%), 5 (3.7%), 32 (23.5%), respectively. Furthermore, the frequency of coated tongue and hairy tongue in heavy smokers was significantly higher than smokers (p=0.01, p<0.0001, respectively) and in smokers was significantly higher than non-smokers (p<0.0001).CONCLUSION: The results of this study indicate that the quality of cigarette smoking has a positive correlation with the probability of occurrence of coated tongue and hairy tongue. 3092 Biochemical NULL 1 12 2007 9 5 50 54 02 06 2014 NULL 3090 Biochemical NULL 1 12 2007 9 5 55 60 02 06 2014 NULL 3093 Biochemical NULL 1 12 2007 9 5 61 64 02 06 2014 NULL