Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
The Effect of Camellia Sinensis Ointment on Perineal Wound Healing in Primiparous Women
7
15
FA
H
Shahrahmani
Research Center of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
hadis.shahrahmani@gmail.com
N
NS
Kariman
Research Center of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
n_kariman@yahoo.com
Y
Sh
Jannesari
Research Center of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
SHARAREHJANNESARI@gmail.com
N
M
Rafieian-Kopaei
Medical Plants Research center, Shahrekord University of Medical Sciences, Shahrekord, Iran
rafieian@yahoo.com
N
M
Mirzaei
Department of Biostatistics and Epidemiology,School of Public Health, Kerman University of Medical Sciences, Kerman,
moghadameh_mirzai@yahoo.com
N
N
Shahrahmani
Department of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
nasim.shahrahmani@gmail.com
N
10.18869/acadpub.jbums.20.5.7
BACKGROUND AND OBJECTIVE: Delay in recovery of episiotomy can lead to infection and persistence of perineal pain. Perineal pain is a stressful problem for primiparous women and has a negative effect on their function.The present study was conducted to determine the effect of Green tea ointment on the healing process of episiotomy.
METHODS: This three-blind clinical trial was conducted on 60 primiparous participated in this research, were divided in two groups: Green tea ointment and placebo ointment. According to the routine of the hospital, 500 mg capsule cephalexin was given to all mothers every six hours for seven days. Mothers used an ointments every 12 hours for a period of ten days in the area of sutures. Wound healing was measured on the fifth and tenth day after delivery using REEDA scale.
FINDINGS: There was no significant difference in demographic features and obstetric variables (for example age and weight newborn). Before the intervention, two groups did not have a significant difference in score of the perineal evaluation scale (p=0.475). The average of this scale on the fifth day in the green tea group was (1.83±1.147) and in placebo group it was (3.33±1.155) on the 10th day, the average of the perineal evaluation scale was (1.2±0.805) for the green tea group and (2.63±1.066) for the placebo group. The average of REEDA scores on the 5th and 10th day after delivery was significantly different between the two groups(p<0.00001)
CONCLUSION: Green tea can improve episiotomy wound healing, due to its healing properties.
Episiotomy, Perineum, Wound Healing, Camellia Sinensis
http://jbums.org/article-1-7538-en.html
http://jbums.org/article-1-7538-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
Effect of Pioglitazone on Antioxidant Capacity and Oxidative Damage after Spinal Cord Injury in Rat
16
22
FA
Z
Jahanbakhsh
1. Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, I.R.Iran.
jahanbakhsh154@yahoo.com
N
H
Ghoshooni
1. Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, I.R.Iran.
ghoshooni287@yahoo.com
N
MT
Mohammadi
Research Center of Neuroscience, Baqiyatallah University of Medical Sciences, Tehran, I.R.Iran
Mohammadi.mohammadt@yahoo.com
Y
M
Salehi
1. Department of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, I.R.Iran.
Mohammadimohammadt@bmsu.ac.ir
N
10.18869/acadpub.jbums.20.5.16
BACKGROUND AND OBJECTIVE: Reduction of the antioxidant capacity and oxidative damage has a crucial role in development of damage after spinal cord injury. Since pioglitazone (PPAR-gamma agonist) have a powerful antioxidant property, the present study aimed to evaluate the effect of pioglitazone on antioxidant capacity and oxidative damage in the injured areas of spinal cord in rat.
METHODS: In the present experimental study eighteen male Wistar rats divided into three groups as follow (n=6); sham, control injured and pioglitazone-treated injured group. Spinal cord injury was performed according to the Ping-Weight Drop (contusion) model in rat. The animals received pioglitazone (3 mg/kg) intraperitoneally at times of 15 min after injury and then each 12 hours until a week. At the end, malondialdehyde level, activity of catalase and superoxide dismutase (SOD) enzymes and also histopathological alterations of spinal cord were assessed.
FINDINGS: Induction of spinal cord injury in control injured animals significantly increased the malondialdehyde levels (56%) and decreased the activity of catalase (48%) and SOD (65%) enzymes compared to sham group (P=0.004, P=0.001 and P=0.008, respectively). Pioglitazone in treated injured group significantly decreased the malondialdehyde levels (38%) and increased the activity of catalase (34%) enzyme compared to control injured group (P=0.038 and P=0.014, respectively). Also, pioglitazone prevented the histopathological changes of injured areas in spinal cord.
CONCLUSION: The findings of present study indicate that treatment with pioglitazone through potentiation of the antioxidant defense capacity of injured spinal cord decreases oxidative damage and also histopathological changes of spinal cord.
Spinal cord injury, Pioglitazone, Oxidative damage, Malondialdehyde, Antioxidant capacity
http://jbums.org/article-1-7224-en.html
http://jbums.org/article-1-7224-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
The Relationship between Chronic Diseases and Disability in Daily Activities and Instrumental Activities of Daily Living in the Elderly
23
29
FA
SR
Hosseini
1. Research Center of Social Determinants of Health, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran
hosseinirezaseyed@gmail.com
N
A
Zabihi
Research Center of Nursing Care, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran
zabihi_alii@yahoo.com
Y
SR
Jafarian Amiri
Research Center of Nursing Care, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran
jafarianamiri@gmail.com
N
A
Bijani
1. Research Center of Social Determinants of Health, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran
alibijani@yahoo.com
N
10.18869/acadpub.jbums.20.5.23
BACKGROUND AND OBJECTIVE: Chronic disease is one of the major causes of disability in doing daily activities. The aim of this study is to determine the relationship between chronic disease and disability in daily activities and instrumental activities of daily living in the elderly.
METHODS: This cross-sectional study was conducted among the elderly of Amirkola. Demographic characteristics (age, gender, level of education and occupation), daily activities and instrumental activities of daily living were collected using a questionnaire. The ability to perform daily activities and instrumental activities was categorized as independently, with the help of others and completely dependent, and ultimately, completely dependent people and those using the help of others were placed in the disability group. The presence of chronic diseases in the elderly was characterized and examined by reviewing the medical records.
FINDINGS: Of 1,500 elderly who were eligible to enter the study, 832 people (55.5%) were male and 668 people (44.5%) were female. In this study, 38 people (2.5%) had a disability in daily activities and 723 (48.2%) had disability in instrumental activities of daily living. The number of associated diseases (p < 0.003, CI-95% = 1.08 – 1.46, OR = 1.261), cognitive impairment (p<0.009, CI-95% = 1.308 – 6.508, OR = 2.917) and old age had a significant relationship with daily activity. The highest significant relationship was between the instrumental activities of daily living and gender (p<0.000, CI-95% = 1.53 – 2.69, OR = 2.029), age (p = 0.000), education level (p = 0.000), the number of associated diseases (P = 0.000, CI-95% = 1.13 – 1.28, OR = 1.2) and cognitive impairment (p = 0.000, CI-95% = 1.487 – 2.596, OR = 1.965).
CONCLUSION: According to the results of this study, the presence of chronic diseases, especially cognitive impairment, is one of the effective factors in disability in daily activities and instrumental activities of daily living
Daily Activity, Chronic Disease, Disability, Old Age
http://jbums.org/article-1-7302-en.html
http://jbums.org/article-1-7302-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
Prediction of Coronary Artery Restenosis in Patients Undergoing Angioplasty
30
37
FA
F
Ebrahimzadeh
Lorestan University of Medical Sciences
farzadebrahimzade2012@gmail.com
N
M
Salehi Veisi
Behbahan Khatam Alanbia University of Technology
salehivaysi@bkatu.ac.ir
N
E
Hajizadeh
Tarbiat Modares University
hajizadeh@modares.ac.ir
N
M
Namdari
Department of Cardiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, I.R.Iran
namdari_m@yahoo.com
Y
10.18869/acadpub.jbums.20.5.30
BACKGROUND AND OBJECTIVE: Coronary artery restenosis following angioplasty may lead to major unwanted cardiac events. This is one of the most important concerns of cardiologists. This study was performed to evaluate the predictors of coronary artery restenosis in patients undergoing angioplasty.
METHODS: In this cohort study, all 2159 patients who referred to Madani Hospital in Khorramabad, Iran for angioplasty between 2004 and 2015 were followed up regarding the incidence of coronary artery restenosis for one or two years (at least 50% stenosis in the place of the previous angioplasty) depending on the type of stent, and clinical variables related to the lesion and procedure were recorded in an information form. Then, agents for predicting coronary artery restenosis were identified based on CART (Classification and Regression Tree).
FINDINGS: Cumulative incidence of coronary artery restenosis was 12.9% (279 patients) in subcategories: non-drug-eluting stent (25.8%, 114 patients), comorbidity of diabetes and hyperlipidemia (under the subcategory of drug-eluting stents, 19%, 32 patients), multiple drug-eluting stents (under the subcategory of non-diabetic patients, 14.6%, 25 patients), comorbidity of hyperlipidemia and drug abuse (under the subcategory of non-diabetic group who use one drug-eluting stent, 12.8%, 16 patients).
CONCLUSION: According to the results of this study, stent type, history of diabetes, number of stents, hyperlipidemia and drug abuse are among the most important predictors of coronary artery restenosis.
Coronary Artery Restenosis, Coronary Angioplasty, Coronary Stent, Data Mining, Classification Tree
http://jbums.org/article-1-7442-en.html
http://jbums.org/article-1-7442-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
The Effect of Training Pregnant Women and Their Husbands on Health Promoting Behaviors during Pregnancy and Postpartum Period
38
47
FA
F
Sanaati
Tabriz University of Medical Sciences
sanaati.favziye@gmail.com
N
S
Mohammad-Alizadeh
Tabriz University of Medical Sciences
alizades@tbzmed.ac.ir
N
M
Mirghafourvand
Research Center of Social Determinants of Health, Tabriz University of Medical Sciences, Tabriz, I.R.Iran
mirg1385@yahoo.com
Y
F
Alizadeh Sharjabadi
1. Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, I.R.Iran
N
M
Galeshi
1. Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, I.R.Iran
N
10.18869/acadpub.jbums.20.5.38
BACKGROUND AND OBJECTIVE: Health promoting lifestyle is any kind of action that is taken to maintain the health of the individual. Healthy lifestyle plays an important role in improving the maternal-fetal outcomes. The aim of this study is to determine the effect of training pregnant women and their husbands on health promoting lifestyle.
METHODS: This clinical trial was conducted among 189 pregnant women in the city of Bukan, Iran. Participants were categorized into three groups: the recipients of the training along with their husbands (the first intervention group), the recipients of the training without their husbands (the second group of intervention) and the routine care recipients (control group). Four sessions of group training were held for mothers of both interventional groups and one group training session was held for the mothers of the first intervention group regarding sleep health, nutrition, physical activity, self-image and sexual issues. Health promoting lifestyle questionnaire (score range: 52 - 208) was completed and assessed before the intervention, eight weeks after the intervention and six weeks after delivery.
FINDINGS: There was no statistically significant difference between the groups before the intervention in terms of the total score of health promoting lifestyle. Eight weeks after the intervention, the mean score of health promoting lifestyle was 162.2±2.5 in the first group, 153.6±2.5 in the second group and 133.4±2.4 in the control group, which was significantly higher in both intervention groups compared to the control group (p<0.001). Six weeks after delivery, the mean score of health promoting lifestyle was 159.8±3.0 in the first group of intervention, 143.1±3.0 in the second group and 133.7±3.0 in the control group, which was significantly higher in the first group of intervention compared to the second group of intervention (p=0.003) and control group (p<0.001).
CONCLUSION: The results of the study showed that training pregnant women along with their husbands or training the women alone improves lifestyle. However, training pregnant women along with their husbands proved to be more effective than training the women alone.
Training, Lifestyle, Pregnancy, Postpartum Period.
http://jbums.org/article-1-7029-en.html
http://jbums.org/article-1-7029-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
Design of Lentiviral Vector of Apoptin and Investigating its Cytotoxic Effect on Reh Acute Lymphoblastic Leukemia Cells
48
53
FA
A
Anjam najmedini
1. Department of Hematology and Blood Banking, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
alianjam1371@yahoo.com
N
R
Vahabpour
2. Department of Medical Lab Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran.
farhang-v-r@yahoo.com
N
F
Jalali
3. Bam University of Medical Sciences, Bam, I.R.Iran
alianjam1371@Gmail.com
N
D
Bashash
Department of Hematology and Blood Banking, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran.
david_5980@yahoo.com
Y
10.18869/acadpub.jbums.20.5.48
BACKGROUND AND OBJECTIVE: Resistance to chemotherapy drugs is one of the most important treatment problems in patients with acute lymphoblastic leukemia. Apoptin due to its ability to induce apoptosis in tumor cells, has an undeniable potential in cancer treatment, especially those that respond lessly to chemotherapy. Therefore, in this study, the effect of induction of apoptin expression on induction of cell death in reh malignant lymphoblasts was investigated.
METHODS: In this experimental study, after culturing of Reh cells (prepared by the Pasteur Institute), the entry of lentiviral vector, metabolic activity and cell proliferation were measured using flow cytometry, MTT and trypan blue at 24, 48, 72 and 96 hours. Real time PCR was also used to determine the apoptin gene expression.
FINDINGS: The results of this study indicate the design and construction of a suitable lentiviral vector that can infect more than 65% of the cells. Also, after infecting the cells with the vector, the apoptin gene expression rate was increased about 10 times to control, and subsequently, the cell viability decreased by 53% time-dependently (p <0.01) . The results also showed that the inhibitory effect of apoptin gene expression on the metabolic activity of Reh cells was about 35% (p<0.01).
CONCLUSION: The results of the study showed that apoptin gene expression has anti-tumor activity in Reh cells and can be used as a promising therapy in ALL.
Apoptin, Lentiviral Vector, Acute Lymphoblastic Leukemia, Reh Cell Li
http://jbums.org/article-1-7239-en.html
http://jbums.org/article-1-7239-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
The Relationship between Atopic Dermatitis and Premenstrual Syndrome in Women Referred to the Skin Clinic of Hamadan
54
60
FA
SZ
Masoumi
Hamadan University of Medical Sciences, Hamadan, Iran
zahramid2001@yahoo.com
N
0000-0002-2045-3707
F
Kazemi
Hamadan University of Medical Sciences, Hamadan, Iran
faridehkazemi21@yahoo.com
N
0000-0001-9525-1010
MR
Sobhan
Hamadan University of Medical Sciences, Hamadan, Iran
mreza_sobhan@yahoo.com
N
0000-0002-6585-9903
SR
Oliaei
Hamadan University of Medical Sciences, Hamadan, Iran
reihaneho@yahoo.com
N
0000-0000-0000-0000
N
Hosseini
Department of Public Health, Faculty of Public Health, Hamadan University of Medical Sciences, Hamadan, I.R.Iran
narmin.hosseini@gmail.com
Y
0000-0000-0000-0000
Gh
Roshanaei
Hamadan University of Medical Sciences, Hamadan, Iran
ghodratollahroshanaei@gmail.com
N
0000-0002-3547-9125
10.18869/acadpub.jbums.20.5.54
BACKGROUND AND OBJECTIVE: One of the factors affecting dermatophyte is hormonal factors, in which atopic dermatitis is more common in adult women. Since one of the psychotic problems regarding reproductive performance of women is premenstrual syndrome, in this study, the association between premenstrual syndrome and atopic dermatitis in reproductive age women was investigated.
METHODS: This case-control study was performed on 82 women aged between 15 and 49 years old in two groups of atopic dermatitis referring to Skin Clinic of Sina Hospital in Tehran and control group including healthy women for atopic dermatitis. Demographic questionnaire and (PSST) Premenstrual Symptoms Screening Test (with score 42-0) were completed and evaluated by both groups.
FINDINGS: The mean age of subjects in the case group was 17.17 ± 4.45 and in the control group was 27.29 ± 8.03 years. The results showed by controlling the possible confounding factors as age, occupation and marital status the probability of having moderate or severe premenstrual syndrome in patients with atopic dermatitis is 13.26 (OR= 13.26, 95% CI: 3.31, 53.07), as compared with healthy subjects.
CONCLUSION: The results showed that there is a strong relationship between moderate to severe menstrual syndrome and atopic dermatitis in women.
Atopic Dermatitis, Premenstrual Syndrome, Case-Control Study, Women
http://jbums.org/article-1-7242-en.html
http://jbums.org/article-1-7242-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
The Relationship between Perceived Stress and Attitude towards Delivery and Choosing Mode of Delivery among Pregnant Women
61
67
FA
A
Sinaei
1. Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran
a.sinaei@hotmail.com
N
Z
Abbaspoor
Research Center of Reproductive Health Promotion, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R.Iran.
Abbaspoor_Z762@yahoo.com
Y
SE
Hashemi
Ahvaz Jundishapur University of Medical Sciences
Esmaeil2140@yahoo.com
N
N
Javadifar
Ahvaz Jundishapur University of Medical Sciences
Javadifar_n@ajums.ac.ir
N
10.18869/acadpub.jbums.20.5.61
BACKGROUND AND OBJECTIVE: Since choosing mode of delivery is one of the most important choices in a woman's life, the factors affecting this choice are necessary to be considered. In recent years, the effect of various psychological factors on attitude towards delivery has been considered. One of these factors is the mother's perceived stress. Therefore, this study was conducted to determine the relationship between perceived stress and attitude towards delivery and choosing mode of delivery among pregnant women.
METHODS: This prospective cohort study was conducted among 305 pregnant women who were at week 32 of their pregnancy or above who referred to selected health centers of Ahvaz in 2016. "Demographic information", "Perceived stress" and "Attitude towards mode of delivery" were collected using a questionnaire. Perceived stress score was from zero to 56 (higher score indicates higher perceived stress), and attitude towards delivery score was from 68 to 204 (higher score indicates more positive attitude towards delivery).
FINDINGS: The mean perceived stress score in subjects with positive, neutral and negative attitudes toward delivery were 27.08±10.86, 25.70±8.82 and 22.36±15.14, respectively, and in women with virginal and cesarean deliveries were 26.45±10.18 and 25.24±10.44, respectively. There was no significant correlation between perceived stress and attitude towards delivery (p=0.22) and choosing mode of delivery (p=0.49).
CONCLUSION: The results of the study showed that there is no relationship between perceived stress and attitude towards delivery and choosing mode of delivery.
Attitudes towards delivery, Choosing mode of delivery, Perceived stress
http://jbums.org/article-1-7175-en.html
http://jbums.org/article-1-7175-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
Type and Rate of Prophylactic Antibiotic Use in the Orthopedic Patients Underwent Elective Surgeries in Shahid Beheshti Hospital in Babol
68
73
FA
A
Shabanian
Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran
ahmad2@yandex.ru
N
MH
Karimi Nasab
Research Center of Orthopedic, Mazandaran University of Medical Sciences, Sari, I.R.Iran
mhkariminasab@gmail.com
N
M
Shayesteh Azar
Research Center of Orthopedic, Mazandaran University of Medical Sciences, Sari, I.R.Iran
mshayestehazar@yahoo.com
N
SM
Esmaeilnezhad Ganji
4. Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R.Ir
smsnganji@yahoo.com
Y
10.18869/acadpub.jbums.20.5.68
BACKGROUND AND OBJECTIVE: Postoperative infection has been one of the most frequent problems in orthopedics that the prescription of antibiotics to prevent surgical infection is an effective strategy to reduce infections after surgery.The aim of this study was investigating type and amount of prophylactic antibiotics used in the orthopedic cases administered in Shahid Beheshti Hospital in Babol, northern Iran.
METHODS: This cross-sectional study was conducted on 450 traumatic and non-traumatic patients underwent elective orthopedic surgeries and received antibiotic prophylaxis during 2015-2016. The necessary data were collected from the patients' records using a predesigned checklist. This checklist consisted of demographic information, type and mechanism of trauma and information related to prophylaxis (name of antibiotic, dosage, administration method, time to start prophylaxis, administration intervals and overall prophylaxis duration).
FINDINGS: Out of 450 patients, 300 (66.7%) were male and others were female. The mean age was 42.37±21.53. The most commonly used antibiotic was cefazolin (n=437, 97.3%) and gentamycin (n=276, 62%), and the lowest was amikacin (n=8, 1.8%). Mean duration of use was 4.92±1.8 days, ranging from 1 to 15 days.
CONCLUSION: The results showed that the use of prophylactic antibiotics is high and they should be administered with more precise control. The most commonly used antibiotic for prophylaxis was cefazolin and the least was amikacin.a
Antibiotic Prophylaxis, Infection, Orthopedics
http://jbums.org/article-1-7407-en.html
http://jbums.org/article-1-7407-en.pdf
Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
1561-4107
2251-7170
20
5
2018
5
1
Assessment of AFT and Cox Models in Analysis of Factors Influencing the survival of Women with Breast Cancer in Yazd city
74
80
FA
H
Fallahzadeh
shahid sadoughi university of medical science
hofaab@yahoo.com
N
M
Mohammadzadeh
Tarbiat modares university
m_morteza@modares.ac.ir
N
nima
pahlevani
kashan university of medical science
drpahlavani@gmail.com
N
Sh
Taghipour
Department of Pathology, Shahid Sadoughi University of Medical Sciences and Health Services, yazd, I.R.Iran
N
V
Pahlevani
Department of Biostatistics and Epidemiology,Faculty of Health, Shahid Sadoughi University of Medical Sciences, yazd, I.R.Iran
vida.pahlevani@gmail.com
Y
10.18869/acadpub.jbums.20.5.74
BACKGROUND AND OBJECTIVE: Breast cancer is one of the most common cancers in women. The statistical methods in the survival analysis of these patients are accelerated time models and Cox model. The purpose of this study is to evaluate two models in determining the effective factors in the survival of breast cancer.
METHODS: The study was an analytical and cohort study of survival analysis. The 538 of the patients referred to Ramezanzade Radiotherapy Center who had breast cancer and recorded survival status as a census from the April 2005 until March 2012 in Yazd. and survived by phone call. The Kaplan-Meier estimate was used to describe the survival of the patients. The research variables included clinical and demographic factors. The choice of final variables in the model was done by the methods of diminishing the dimension and all possible Cox regressions by the acaian criterion. Then, the best accelerated time model was considered Getting different distributions was also determined by the Akayake criteria.
FINDINGS: The most effective Cox model among all Cox models was variables including Age, Her2 and Ki67 variables (AIC = 30270). The generalized gamma model was the most optimal accelerated time model (AIC 463.966). Her2 was significant in both accelerated and cox models(p-value<0.05), but the Ki67 variable was not significant. (p-value>0.05).
CONCLUSION: In both accelerated time- Generalized Gamma- models and Cox Models, the Her2 variable was identified as a risk factor for breast cancer and There is a positive impact on the risk of death and reduced survival.
Breast Cancer, Ki-67 Antigen, HER2/neu protein, Survival Analysis
http://jbums.org/article-1-6918-en.html
http://jbums.org/article-1-6918-en.pdf