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:: Volume 23, Issue 1 (3-2021) ::
J Babol Univ Med Sci. 2021; Volume 23 Back to browse issues page
Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
Z Salimi , F Moradpour , F Zarei , Z Rashidi , MR Khazaei , SM Ahmadi * , F Khazaei
1. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, I.R.Iran , ahmdymjtby41@gmail.com
Abstract:   (1511 Views)
BACKGROUND AND OBJECTIVE: Tacrolimus belongs to the family of calcineurin inhibitors and is extensively used as an immunosuppressive drug after allogeneic organ transplant. According to the inhibitory effects of calcineurin on synaptic plasticity and memory functions, it seems that the administration of tacrolimus leads to changes in the electrophysiological responses and memory functions. Therefore, this article includes studies in which tacrolimus involvement in cognitive functions such as synaptic plasticity, learning and memory are investigated, and the possible mechanism of the effect of tacrolimus on synaptic plasticity and memory are explained.
METHODS: In this narrative review article, we searched PubMed and Google Scholar databases using the keyword “Tacrolimus”, “Calcineurin”, “Synaptic Plasticity”, “Learning”, “Memory”, and “Free radicals” to provide an overview of effects of tacrolimus on cognitive functions. Finally, articles published on these topics between 1987 and 2021 were investigated.
FINDINGS: Among the 5632 sources found, 72 articles were considered appropriate for the purpose of the research. Findings support that the administration of tacrolimus (TAC) improves cognitive functions such as learning, memory, and synaptic plasticity. Furthermore, TAC has neuroprotective effects against oxidative stress-mediated cognitive dysfunctions.
CONCLUSION: The results of the study showed that TAC may improve learning, memory, and synaptic plasticity, possibly by calcineurin inhibition, reducing the level of free radicals, and altering calcium and glutamate levels.
Keywords: Tacrolimus, Calcineurin, Synaptic Plasticity, Learning, Memory, Free Radicals.
Full-Text [PDF 349 kb]   (441 Downloads)    
Type of Study: Review | Subject: Pharmacology
Received: 2021/02/16 | Accepted: 2021/04/24 | Published: 2021/11/16
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Salimi Z, Moradpour F, Zarei F, Rashidi Z, Khazaei M, Ahmadi S et al . Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article. J Babol Univ Med Sci 2021; 23 (1) :359-368
URL: http://jbums.org/article-1-9940-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 1 (3-2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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