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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
This Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0
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:: Volume 3, Issue 1 (1-2001) ::
J Babol Univ Med Sci. 2001; Volume 3 Back to browse issues page
Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
S Shahabi * , AA Moghadam Nia
Abstract:   (9217 Views)
Objective: Excitatory amino acids (EAA) and noradrenaline are known as a neurotransmitter, which stimulate gonadotropin secretion in female and male animals. This study was designed to evaluate the involvement of central noradrenaline system on FSH secretion induced by EAA in adult rats. Methods: Rats were implanted with monolateral cannula through the LC-SC (Locus Coeruleus-Sub Coeruleus) by stereotaxy. Then saline or glutamate (2 mg/ml) was injected into the cannula. Blood samples were drawn just 10 min after injection and were prepared for IRMA (Immunoradiometric Assay). For investigating the involvement of LC-SC in noradrenergic system, DSP-4 was used as an injection bilaterally one week before glutamate. Findings: Microinjection of glutamate significantly increased the plasma level of FSH in comparison to saline in control group. Pretreatment with DSP-4 significantly decreased the plasma level of FSH before glutamate injection. Conclusion: The results indicated that LC-SC in adult rats is one of the major sites affected by EAAs on FSH secretion by noradrenergic neurons.
Keywords: Central noradrenergic system, Locus coeruleus nucleus, Excitatory amino acid, Follicle stimulating hormone (FSH), Rat
Full-Text [PDF 1231 kb]   (1714 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/05/26 | Published: 2014/05/26


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Shahabi S, Moghadam Nia A. Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids. J Babol Univ Med Sci 2001; 3 (1) :14-20
URL: http://jbums.org/article-1-2880-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3, Issue 1 (1-2001) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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