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Efficacy of Terbinafine 1% cream versus Clotrimazole 1% cream in the treatment of Pityriasis Versicolor
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SM Rezvani,   , SAA Sefid Gar |
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Abstract: (64242 Views) |
BACKGROUND AND OBJECTIVE: Terbinfine a member of allylamines group is a new class of antimycotic agents that blocks sterol biosynthesis in the fungi through inhibition of sequlene epoxidase and with consequent sequalene accumulation due to a primarily fungicidal process. Terbinafine is very effective on various fungi as an oral and topical antifungal agent. The aim of this study was to compare the antifungal efficacy of terbinafine 1% cream with clotrimazole 1% in patients with pityriasis versicolor.
METHODS: This clinical trial study was performed on 50 patients (30 males and 20 females) with mean age of 20 years (aged between 15-55 years) who randomly treated with terbinafine and clotrimazole for 4 weeks. The efficacy of drug and improving process evaluated mycologically and clinically before starting the study and at the end of each week. A patient was considered mycologically cured when direct microscopy was negative and clinically cured when all clinical parameters were considered negative.
FINDINGS: Negativizations of all clinical parameters were observed within 2 weeks in 60% of terbinofine and 35% clotrimazole recipients. At the end of four weeks, disappear of lesions were seen in 90% and 80%, respectively (p<0.05). The percentage of negativization of direct microscopy in terbinafine group was 1.4 fold higher than that clotrimazole group after 2 weeks of treatment. At the end of therapy, 95% of terbinafine and 90% of clotrimazole treated subjects were clinically cured (p>0.05). Both drug eruptions and intolerance in two treated groups were similar.
CONCLUSION: Although the efficacy of the both drugs is similar, but considering the expense of therapy, clotrimazole is preferred regimen for therapy of tinea versicolor. |
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| Keywords: Pityriasis versicolor, Fungal infection, Terbinafine, Clotrimazole |
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Full-Text [PDF 261 kb]
(3765 Downloads)
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Type of Study: Research |
Subject:
Biochemical
Accepted: 2014/06/1 | Published: 2014/06/1
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