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The Effect of Iranian Propolis on Oral Mucositis Induced by X-Ray Irradiation in Rats
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M Rouhi    , M Motallebnejad , HR Nouri , M Seyedmajidi , D Moslemi , A Bijani , S Kazemi , F Asgharpour * |
| 4.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , f_asgharpour@yahoo.com |
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Abstract: (67 Views) |
Background and Objective: Ionizing radiation in the treatment of head and neck cancers causes destructive effects on the oral mucosa; the most common complication of cancer therapy is oral mucositis. This study aimed to investigate the effect of Iranian propolis as a natural substance on the prevention and treatment radiotherapy- induced mucositis in rats.
Methods: In this experimental study, 48 adult Wistar rats were randomly divided into four groups: the saline group (C), the propolis-treated group (P, receiving 400 mg/kg), the propolis and X-ray radiation group (PR, receiving 400 mg/kg), and the saline and X-ray radiation group (SR). Groups PR and SR were exposed to 15 Gy of X-ray radiation. Rats received daily intraperitoneal injections of propolis (groups P and PR). The severity of oral mucositis was evaluated using the Parkins scale after radiation until day 10. On days 5 and 10, histopathological samples from the middle third of the rats' tongues were collected and analyzed.
Findings: The severity of mucositis increased in all groups from day 1 to day 10, but it was significantly lower in the PR group compared to the SR group on days 4, 6 and 10 (p<0.001). Histopathological changes in irradiated groups were significantly more severe than in non-irradiated groups (p<0.001). Additionally, the SR group exhibited the lowest body weight compared to the other groups on day 10 (p<0.001).
Conclusion: Based on the findings of this study, Iranian propolis appears to be effective in the treatment and management of radiation-induced mucositis. It is recommended as a suitable therapeutic option for alleviating mucositis symptoms and reducing oral lesions. |
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| Keywords: Propolis, Mouth, Mucositis, X-Ray. |
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Type of Study: Experimental |
Subject:
Dentistry (Oral Diseases)
Received: 2024/09/7 | Accepted: 2025/01/20
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