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Determining the Factors That Affect Survival and Recurrence Rate in Patients with Endometrial Cancer
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M Sohrabi    , M Vakili Sadeghi , D Moslemi , H Shirafkan , Sh Yazdani * , Z Pahlavan |
| 5.Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, I.R.Iran. , shahla_yazdani_1348@yahoo.com |
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Abstract: (116 Views) |
Background and Objective: Endometrial cancer is the sixth most common cause of cancer-related death in women. Out of 320,000 women diagnosed with endometrial cancer, 76,000 die each year. Considering the prevalence and mortality rate of this disease in Iran, the present study was conducted to determine the factors affecting survival and the recurrence rate in patients with endometrial cancer.
Methods: In this cohort study, all patients who referred to the Oncology Clinic of Ayatollah Rouhani Hospital and the Gynecological Cancer Center from 2008 to 2020 with endometrial carcinoma undergoing surgical and chemoradiotherapy treatment were studied. Demographic and clinical data were recorded in a checklist, and survival, recurrence, and recurrence-free survival rates were assessed during follow-up 1-5 years after surgery by telephone or based on available information, and finally, the findings were statistically analyzed and reported.
Findings: The follow-up period was 42.32±72.5 months, the mean age was 56.63±8.83 years, and 82.3% of patients had no recurrence after surgery. The median overall survival was 122.46±7.30 months and was significant based on disease grade (p=0.001). The effect of age, stage, and grade on survival was significant (p=0.004). The risk of death in high-risk individuals was 6.48 times higher than low-risk individuals (p=0.004), and most deaths (81.2%) occurred in the surgery-radiotherapy group. Compared with chemoradiotherapy, surgery and surgery-radiotherapy significantly reduced the risk of death by 98% and more than 80%, respectively (p=0.002, p=0.024). Recurrence was significant based on stage and was more frequent in high-risk patients (p=0.01), and the majority of those without recurrence were low-risk patients. Most recurrences were abdominal in high-risk individuals, and pelvic and vaginal in low-risk individuals.
Conclusion: According to the results of this study, tumor stage and grading, age, and treatment methods are among the factors affecting the survival of patients with endometrial cancer, and appropriate follow-up of patients with endometrial cancer can lead to timely identification of recurrence and treatment of these patients.
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| Keywords: Endometrial Cancer, Recurrence, Survival, Radiotherapy. |
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Full-Text [PDF 458 kb]
(20 Downloads)
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Type of Study: Research |
Subject:
Obstetrics and Gynecology
Received: 2024/07/27 | Accepted: 2024/12/2 | Published: 2025/12/1
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