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Investigating the Protective Effect of Betaine on Inhibition of Liver Damage Caused By Rifampin in Rats
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P Peiravi    , H Mohammadi * , A Rashidiani-Rashidabadi , M Mohammadi , A Adineh |
| 2.Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad,, I.R.Iran. , Hamidrezamohammadi65@yahoo.com |
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Abstract: (186 Views) |
Background and Objective: Rifampin is one of the antibiotic drugs that is usually used to treat tuberculosis and is considered a strong toxic agent for the liver. This study was conducted to investigate the effects of Betaine administration on Rifampin-induced liver damage in rats.
Methods: This experimental study was conducted on 60 male Wistar rats in 6 groups of 10. Liver damage and induction of oxidative stress were caused by oral administration of Rifampin 100 mg per kg of body weight for 14 consecutive days. Different doses of Betaine (50, 10 and 100 mg per kg of body weight) were administered by gavage to the sick mice. At the end of the period, liver damage caused by Rifampin was investigated by examining serum biochemical factors (ALT, AST, LDH, Bilirubin), levels of reactive oxygen species (ROS), glutathione (GSH), antioxidant capacity (FRAP), lipid peroxidation (LPO) and histopathological changes in liver tissue were evaluated.
Findings: The serum level of ALT in the group that received Rifampin (201±7821) was significantly higher than the control group (26±281) (p=0.0031), the serum level of AST in the group that was prescribed only Rifampin (684±118) compared to the control group (50±1021) was also significantly higher (AST=706). The amount of ROS in the patient group (216000±1001) compared to the control group (982090±8332) was significantly increased. (P=0.002) Also, the amount of LPO in the group that received Rifampin (8.24±1.63) compared to the control group (1.19±0.13) had a significant increase (P=0.021).
Conclusion: The results of the study showed that Betaine can reduce liver damage caused by Rifampin and its consequences. |
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| Keywords: Betaine, Liver Damage, Rifampin, Oxidative Stress. |
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Type of Study: Experimental |
Subject:
Pharmacology
Received: 2023/06/9 | Accepted: 2023/11/12
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