|
Investigating the Association between Two Polymorphisms Rs2235749 and Rs910080 in the PDYN Gene and Susceptibility to Addiction
|
A Hamta *    , P Ghasemian Safaei , R Bayatian |
| 1.Department of Biology, Faculty of Sciences, Arak University, Arak, I.R.Iran. , a-hamta@araku.ac.ir |
|
|
Abstract: (206 Views) |
Background and Objective: Studies show that genetic factors, including polymorphisms, contribute to individual differences in the risk of developing addiction. One of the important genes whose polymorphisms are associated with the risk of developing addiction is the PDYN gene. The aim of this study is to investigate the association between two polymorphisms, rs2235749 and rs910080, in the PDYN gene and the susceptibility to addiction.
Methods: In this case-control study, blood samples from 80 individuals with a history of heroin or methamphetamine addiction and 80 healthy individuals with no history of use, living in Markazi province, were genotyped and compared. The genotypes of the individuals in the two groups were determined using PCR-RFLP and agarose gel electrophoresis techniques, and were examined and compared.
Findings: A significant difference was observed between the addicted and control groups for the genotypes of the rs910080 polymorphism (p<0.000). In this study, the frequencies of TT, CC, and CT genotypes were 43.75%, 15%, and 41.25% in the control group, and 25%, 46.25%, and 28.75% in the addicted group, respectively. No statistically significant difference was observed between the addicted and control groups for the genotypes of the rs2235749 polymorphism, and the frequencies of TT, CC, and TC genotypes were 23.75%, 40%, and 36.25% in the addicted group, and 22.5%, 33.75%, and 43.75% in the control group, respectively.
Conclusion: According to the results of this study, the CC genotype of the rs910080 polymorphism of the PDYN gene is significantly associated with addiction and increases the risk of developing addiction, while people with the CT and TT genotypes have a lower susceptibility to addiction. |
|
| Keywords: Heroin, Polymorphism, Methamphetamine, PDYN. |
|
|
Full-Text [PDF 347 kb]
(30 Downloads)
|
Type of Study: Case-Control |
Subject:
Genetics, Cell and Molecular Biology
Received: 2024/08/10 | Accepted: 2024/12/2 | Published: 2025/11/30
|
|
|
|
|
|
|
| Send email to the article author |
|
|
