2024-03-29T10:45:08+03:30
http://jbums.org/browse.php?mag_id=435&slc_lang=fa&sid=1
435-5581
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
The Relationship between Chronic Musculoskeletal Pain and Vitamin D Deficiency in the Elderly Population of Amirkola, Iran
M
Alipour
SR
Hosseini
hosseinirezaseyed@gmail.com
P
Saadat
@gmail.com
A
Bijani
BACKGROUND AND OBJECTIVE: Chronic musculoskeletal pain may persist for more than three months and is
often resistant to treatment. The aim of this study was to examine the
relationship between chronic musculoskeletal pain and vitamin D deficiency in
the elderly population of Amirkola, Iran.METHODS: This cross-sectional study was part of a health survey on
the elderly population of Amirkola (AHAP=Amirkola
Health and Ageing Project), including 1616 senior citizens, aged ≥ 60 years. Overall,
857 individuals without rheumatoid arthritis, cancer, depression, diabetes or
osteoarthritis were enrolled in this study. Demographic data were collected and
a questionnaire on chronic musculoskeletal pain was applied. The anatomical
site of pain was determined by inquiring the elderly. The serum level of
vitamin D was measured in two groups with and without chronic pain, using the
ELISA method. Vitamin D deficiency, insufficiency and sufficiency were defined
as serum vitamin D levels of < 20, 20-29.99 and ≥30 ng/ml, respectively.FINDINGS: Among 857
participants, 599 (69.9%) and 258 (30.1%) cases were male and female,
respectively. Moreover, 666 participants (77.7%) complained of chronic pain.
The most common sites of pain were the knees (54%), back (40%), feet (35.7%)
and shoulders (27.5%), respectively. Also, 41.9% of the elderly had vitamin D
deficiency. However, vitamin D level was not significantly different between
the two groups (with and without chronic pain), and frequency of chronic pain
did not significantly vary between these groups. Based on the logistic
regression model, gender (OR=2.73, 95%CI=1.78-4.21, p=0.001), body mass index
and physical activity (OR=0.42, 95% CI=0.28-0.62, p=0.001) had significant
impacts on chronic pain.
CONCLUSION: The
results showed no significant relationship between vitamin D level and chronic
musculoskeletal pain in the elderly population of Amirkola, Iran.
Body mass index
Chronic pain
Elderly
Physical activity
Vitamin D
2015
10
01
7
14
http://jbums.org/article-1-5581-en.pdf
10.22088/jbums.17.10.7
435-5278
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
Effects of Yakson Therapeutic Touch on the Behavioral Response of Premature Infants
F
Eshghi
eshghifateme@yahoo.com
S
Iranmanesh
B
Bahman Bijari
F
Borhani
M
Motamed Jahromi
BACKGROUND AND OBJECTIVE: Due to incomplete physical development, premature infants are susceptible to various sources of stress. Therapeutic touch is considered as an effective method to reduce stress in neonates. This study aimed to compare the effects of Yakson therapeutic touch and routine nursing care on the behavioral response of premature infants.
METHODS: This quasi-experimental study was conducted on 60 premature infants aged 26-34 weeks, admitted at the neonatal intensive care unit (NICU) of Afzalipour Hospital of Kerman, Iran. Subjects were randomly selected by minimization and equally divided into two groups of intervention and control (N=30). Infants in the intervention group received Yakson massage therapy for 5 days, twice daily for 15 minutes, and infants in the control group received routine care. Behavioral responses of infants, including the status of sleep, waking and restlessness, were evaluated using Anderson Behavioral State Scale (ABSS) before and after intervention.
FINDINGS: In this study, mean scores of ABSS in preterm infants of the intervention and control groups was 4.83±0.14 and 10.63±0.14, respectively. Moreover, there was a significant difference between the scores of behavioral response after the intervention between the groups (p=0.001).
CONCLUSION: According to the results of this study, increased scores of sleep status in the infants of the Yakson therapy group indicated that this method could be effective in the provision of nursing care for premature infants admitted at the NICU.
Prematurity
Yakson
Human Touch
Behavioral Response
2015
10
01
15
21
http://jbums.org/article-1-5278-en.pdf
10.22088/jbums.17.10.15
435-5361
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
The Relationship between Level of Vitamin C in Follicular Fluid and Maturation of Oocytes and Embryo Quality in Patients Undergoing In-vitro Fertilization
S
Saffari
MH
Bahadori
H
Sharami
P
TorabZadeh
M
Goudarzvand
BACKGROUND AND OBJECTIVE: Oxidative stress and its adverse effects in vitro or on the body can reduce the number of reproductive cells and embryo quality. Given the fact that vitamin C is a natural antioxidant with a protective role, in this study we aimed to evaluate the relationship between the level of vitamin C in follicular fluid (FF) and maturation of oocytes and embryo quality of patients undergoing in vitro fertilization (IVF).
METHODS: This cross-sectional study was performed on the eggs and embryos of 50 patients admitted to IVF unit of Al Zahra Hospital, Rasht, Iran. Patients underwent the same mediations used to induce ovulation, and then they were injected 10000 units of human chorionic gonadotropin. Finally, they underwent 36 hours of follicle suction. Vitamin C level in FF was measured by biochemical methods. Maturation of oocytes and embryo quality were examined with inverted light microscope.
FINDINGS: After examining 583 eggs and 275 embryos the following results were obtained: the percentage of metaphase II oocytes in vitamin C level of less than one was 81.3% (412), but when compared to vitamin C level of one or more, it was 71.1% (54), which were significantly different (p=0.038). In the sub-classification, vitamin C level (0.5-1 mg/dl), MII oocyte frequency and the two pronuclei embryos were higher but the difference was not statistically significant.
CONCLUSION: The results showed that the quality of oocyte maturation and embryos in lower levels of vitamin C levels had improved, as compared to higher levels.
Infertility
In-vitro fertilization
Levels of vitamin C
Oocytes
Follicular fluid
Embryo quality
Antioxidant
2015
10
01
22
27
http://jbums.org/article-1-5361-en.pdf
10.22088/jbums.17.10.22
435-5355
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
Effects of Maternal Empowerment Program on the Length of Hospitalization and Readmission Rate of Premature Infants
S
Karbandi
A
Momenizade
M
Heydarzade
SR
Mazlom
M
Hassanzade
BACKGROUND AND OBJECTIVE: Premature infants because special needs might be admitted at the neonatal intensive care unit for days to recover. Despite medical advances, rate of readmission among preterm infants is relatively high, causing economic and psychological problems for families. This study aimed to evaluate the effects of empowerment Mother Program on length of stay and readmission rate of preterm infants.
METHODS: This randomized clinical trial was conducted on 70 mothers with premature infants, divided into two groups of intervention and control. Educational-behavioral empowerment program was performed in four stages: 2-4 days after admission (stage one), 2-4 days after completing the first stage (stage two), 1-3 days before discharge (stage three), and one week after discharge (stage four). During each stage, mothers in the intervention group listened to selected audio files, and subjects in the control group received usual care based on hospital policies. In two stages, mothers were regularly enquired about the readmission rate of neonates via phone calls within 10-15 days after discharge. In addition, length of hospitalization was extracted from the medical records of the infants. IRCT:N201410151954.
FINDINGS: In this study, mean of hospitalization in the intervention and control groups was 10.85±5.93 and 13.85±7.65 days, respectively (p=0.03). Moreover, no statistically significant difference was observed in the readmission rate of infants one month after discharge.
CONCLUSION: According to the results of this study, the empowerment program caused a significant reduction in the length of hospital stay. However, it had no significant effects on the rate of readmission in the studied neonates
Empowerment Program
Length of Hospital Stay
Readmission Rate
Premature Infants
2015
10
01
28
33
http://jbums.org/article-1-5355-en.pdf
10.22088/jbums.17.10.28
435-5346
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
Associations of Oxidative Stress Indices in Infants Born via Natural Delivery with Entonox Exposure
K
Vakilian
dr.kvakilian@arakmu.ac.ir
A
Ranjbar
BACKGROUND AND OBJECTIVE: Entonox is an
odorless, tasteless gas and the first anesthesia agent used in obstetrics. To
date, no studies have evaluated the effects of Entonox on oxidative stress.
This study aimed to investigate the association between infant oxidative stress
indices in mothers exposed to Entonox gas during vaginal delivery.
METHODS: This cohort study was conducted on 120
pregnant women undergoing natural labor. Subjects were divided into two groups
of delivery with and without exposure to analgesic Entonox (N=60). After
delivery, 5 ml of arterial blood was obtained from the umbilical cords of all
infants, and indicators such as malondialdehyde, thiols and total antioxidant
capacity were measured and evaluated in each group.
FINDINGS: In this study, there were no
significant differences in the indicators of oxidative stress between the study
groups. Values obtained in groups with and without Entonox exposure were
respectively as follows: total antioxidant capacity (1.33±1.21 vs. 1.59±1.3, p=0.84),
thiols (0.363±0.313 vs. 0.238±0.225, p=0.07), lipid peroxidation (4.60±2.76 vs.
5.31±3.19, p=1).
CONCLUSION: According to the results
of this study, exposure to Entonox had no significant effects on the indicators
of infant oxidative stress. Therefore, Entonox exposure could be used as a safe
analgesic approach in natural delivery.
Oxidative Stress
Natural Delivery
Painless Delivery
Infant
2015
10
01
34
38
http://jbums.org/article-1-5346-en.pdf
10.22088/jbums.17.10.34
435-5349
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
An Investigation of the Effect of Hypoxia on Expression of 107-miR in Gastric Cancer Cell Lines MKN-45 and AGS
N
Ayremlou
H
Mozdarani
mozdarah@modares.ac.ir
SJ
Mowla
A
Delavari
BACKGROUND AND OBJECTIVE: Hypoxia in solid
tumors is the major cause of cancer treatment resistance. Thus, identifying the
appropriate indicators of hypoxia in tumors is of great importance for
appropriate tumor prognosis and choosing the best treatment methods. This study
aims to investigate the modulation of miR-107 expression, as a biomarker of
hypoxia and its association with gastric cancer cells.
METHODS: MKN45 and AGS gastric cancer cells were
purchased from Tehran Pasteur Institute and then, were cultured under normal
oxygen conditions (CO2 5% and O2 95%) and hypoxia (CO2
5% and N2 95%). Finally, miR-107 and HIF-1-α expressions were
evaluated every 24 to 48 hours.
FINDINGS: The results of the study showed that
through hypoxia induction, HIF-1-α expression in MKN-45 cell lines increased by
extending treatment duration (24 and 48 hours) 2.3 and 3.8 times, respectively,
(p=0.04 and p=0.002), and in AGS cell lines HIF-1-α expression increased 2.2
and 3.8 times (p=0.03 and p=0.005). In addition, miR-107 expression in MKN-45
increased during this time by 2.2 and 3.1 times (p=0.01 and p=0.0001), while in
AGS cell lines it was by 2.4 and 4 times (p=0.002 and p=0.0001).
CONCLUSION: It was demonstrated that hypoxia induction in gastric cancer
cells could modulate the expression of miR-107.
Gastric cancer
HIF-1-alpha
Hypoxia
miR-107
2015
10
01
39
45
http://jbums.org/article-1-5349-en.pdf
10.22088/jbums.17.10.39
435-5326
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
Early Detection of blaTEM in Klebsiella Isolates by the Molecular Polymerase Chain Reaction Method
S
Bostandoost nikoo
MH
Shahhosseiny
shahhosseiny@yahoo.com
MR
Zolfaghari
M
Rahbar
BACKGROUND AND OBJECTIVE: Obtaining information regarding pathogenesis and prevalence of extended spectrum beta-lactamase (ESBL) producing genes seems to be necessary, since it can promote prevention modalities and treatment of the infections caused by bacterias such as Klebsiella. The aim of this study was early identification of the blaTEM gene in Klebsiella, using polymerase chain reaction (PCR) technique.
METHODS: In this cross-sectional study, conducted form April to September 2013, 70 Klebsiella isolates were extracted from clinical samples (i.e., wound, urine, sputum and blood) using biochemical tests, including non-state fermentation and triple sugar iron, negative indole, motile and methyl red, as well as positive Voges–Proskauer and urease tests. Subsequently, the frequency of ESBL producing strains was determined by means of combined disk method. DNA was extracted by boiling and was investigated for the presence of TEM gene using the PCR approach.
FINDINGS: In the 70 Klebsiella isolates, 11 cases of ESBL phenotype were observed, of which 10 cases contained TEM beta-lactamase resistance gene. In addition, 9 out of 59 samples (26%) of negative ESBL in antibiogram, were determined positive in terms of blaTEM gene using PCR method.
CONCLUSION: Given the increasing prevalence of ESBL producing strains and poor diagnosis rate of antibiotic resistance through antibiogram method, applying more accurate techniques such as PCR is highly recommended.
BlaTEM Resistance Gene
Extended Spectrum Beta-lactamases
Polymerase Chain Reaction
Antibiogram
2015
10
01
46
52
http://jbums.org/article-1-5326-en.pdf
10.22088/jbums.17.10.46
435-4883
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
A Comparison between the Molecular Identity of Mycoplasma Hominis in Urine Samples of Patients with Urinary Tract Infections and Similar Strains Available in GenBank
H
Eftekhari
B
kheirkhah
b.kheirkhah@srbiau.ac.ir
B
Amirheydari
BACKGROUND AND OBJECTIVE: Mycoplasmal infections are one of the most important urinary infections. Various studies have applied culture studies and biochemistry to separate the bacteria from the urinary tract. However, it should be noted that molecular and phylogenetic analyses are based on epidemiologic evaluations. The purpose of this study was to determine the molecular identity of Mycoplasma hominis, separated from the urine samples of patients with urinary tract infections in Kerman, Iran and compare the sequences with other strains in GenBank.
METHODS: In this cross-sectional study, 5 ml mid-stream urine samples of 50 patients with urinary tract infections were collected. After the specialists confirmed the diagnosis of urinary tract infections in patients via paraclinical tests, segments of 16S rRNA gene were amplified, using specific primers of Mycoplasma hominis via polymerase chain reaction (PCR) technique. After purifying the PCR product, the sequences of bacterial strains were determined. Then, the sequences were aligned and the strains were compared with each other and other strains available in GenBank, using BioEdit software.
FINDINGS: Three Mycoplasma hominis strains were separated in this study. The alignment of sequences and comparison with strains available in GenBank did not indicate a significant difference between the strains. Based on phylogenetic analyses in this study and the phylogenetic tree, one of the strains (H6) was highly similar to the strains of GenBank and belonged to the same family. On the other hand, two strains (H11 and H15) were of a different lineage and were completely different from other strains in the present study and those recorded in GenBank.
CONCLUSION: In this study, after applying the PCR technique and bacterial separation, the sequences were compared with those in GenBank. All three strains were Mycoplasma hominis, based on 16S rRNA gene sequence.
Mycoplasma hominis
Urinary tract infection
Polymerase chain reaction
Nucleotide sequence
16S rRNA gene
2015
10
01
53
59
http://jbums.org/article-1-4883-en.pdf
10.22088/jbums.17.10.53
435-5251
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
A Comparative Study of the Effects of Sodium Arsenite and Nanoparticles of Sodium Arsenite on the Apparent and Skeletal Malformations in Rat Embryos
H
Njafzadeh Varzi
najafzadeh@scu.ac.ir
M
Khaksari Mahabadi
A
Haji
BACKGROUND AND OBJECTIVE: Arsenic causes
congenital anomalies in humans and animals, and nanoparticles
of sodium arsenite are highly capable
of inducing apoptosis. Since the effects of nanoparticles of sodium arsenite on fetal malformations have not been evaluated yet, this
study aims to compare the effect of sodium arsenite and nanoparticles of sodium
arsenite on skeletal malformations in rat embryos.
METHODS: This in-vitro study was performed on
four groups of pregnant rats (n= 23 rats). Mating was confirmed by observation of
vaginal plug. On the tenth day of gestation, pregnant rats in different groups
received intraperitoneal normal saline (n=7 rats), sodium arsenite (11 mg/kg)
(n=5 rats), nanoparticles of sodium arsenite (1 mg) (n=5
rats) and nanoparticles of sodium arsenite (11 mg) (n=7
rats). All the rats were euthanized on the twentieth day of pregnancy and their
embryos were removed, their weight and length were measured, and then were
stained with alizarin red and alcian blue. The skeletal system abnormities of
embryos such as cleft palate, malfunctions or malformations in ribs,
vertebrae, spine, sternum, arms, legs, fingers and reduction of ossification
were evaluated
by a stereomicroscope, and then compared with the control group.
FINDINGS: Sodium arsenite and nanoparticles of
sodium arsenite reduced
fetal weight from 5 g in the control group to 2 g (p≤0.033) and also, decreased
fetal length from 38 cm to 28 cm in the control group (p≤0.023). The weight and
length of fetuses were significantly reduced in nanoparticles
of sodium arsenite group (11 mg), as compared to sodium arsenite group (p≤0.033).
There were no skeletal malformations in the control group, while the percentage
of anomalities was between 3% and 47% in the intervention group.
CONCLUSION: Nanoparticles of sodium
arsenite, as compared to sodium arsenite, were more effective in reducing fetal
length and weight and in diminishing the rate of skeletal
malformations such as cleft palate
Fetal Rats
Skeletal Anomalies
Sodium Arsenite
2015
10
01
60
66
http://jbums.org/article-1-5251-en.pdf
10.22088/jbums.17.10.60
435-5383
2024-03-29
10.1002
Journal of Babol University of Medical Sciences
J Babol Univ Med Sci
1561-4107
2251-7170
10.22088/jbums
2015
17
10
Predicting Factors of Radiosensitivity in Individual Radiotherapy
Sh
ghasemi
A
Shabestani Monfared
monfared_ali@yahoo.com
S
Borzoueisileh
E
Zabihi
M
Amiri
S
Abedian
BACKGROUND AND OBJECTIVE: Radiation dose in oncology protocols is different for each patient according to the type and grade of the tumor, as well as adjuvant therapies. In the current treatment regimens, some predicting factors of individual radiosensitivity have not been considered. Individual radiotherapy can lower side effects through radiation dose reduction with respect to tumor control. In this study, the most determining factors for predicting radiosensitivity, used for individual radiotherapy, were reviewed.
METHODS: Data were retrieved through searching Sciencedirect, PubMed, Google scholar, Iranmedex and SID databases. The titles and abstracts of Persian and English articles were searched using keywords including: radiotherapy, the rate of cell proliferation, tumoral hypoxia, inherent radiosensitivity, tumor cell cycle, inhibitor factors of tumor, cancer stem cells, field dose radiation, apoptosis and predicting factors of radiosensitivity.
FINDINGS: Out of 90 articles, 25 original articles and reviews on predicting factors of the rate of radiosensitivity were thoroughly studied. Multiple factors, such as the presence of hypoxic zone and its size, inherent radiosensitivity and apoptosis, are crucial in determining individual radiation dose. Other factors, including previous history of exposure, blood type, left-or right-handedness and physical factors, should also be considered.
CONCLUSION: With respect to the physical, chemical, and biological parameters influencing individual radiosensitivity, radiotherapy individualization can promote tumor treatment and diminish side effects of radiotherapy on normal tissue.
Radiosensitivity
Radiotherapy
Radiation Dosage
Side Effects
2015
10
01
67
73
http://jbums.org/article-1-5383-en.pdf
10.22088/jbums.17.10.67