2024-03-29T08:26:25+03:30 http://jbums.org/browse.php?mag_id=223&slc_lang=fa&sid=1
223-2487 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 EFFECT OF LONG TERM CONSUMPTION OF AQUEOUS DATE FRUIT EXTRACT ON ANALGESIA RESPONSE IN MALE RAT M Asadi Shekaari, V Sheibani, HA Ebrahimi, M Rismanchian T Kalantari Pour MR Afarinesh BACKGROUND AND OBJECTIVE: Pain is one of the first symptoms of diseases. So many efforts have been applied for pain determination and relief. The aim of this study was to investigate the analgesic effects of chronic consumption of aqueous date fruit extract (ADFE) in male rat.METHODS: This experimental study was performed on 48 male NMRI rats (250±25gr). Animals divided into two groups as follow: control and experimental group. ADFE (10%) was added to drinking water of the experimental group for 21 days. Control group received distilled water. Then formalin, tail flick and paw pressure tests were applied for comparing the two groups.FINDINGS: Aqueous extract of date fruit (10%) in chronic phase of formalin test showed significant difference between two groups in regard to pain decrease (p<0.05), while there was no significant difference between the two groups in acute phase of formalin test and also tail flick and paw pressure tests.CONCLUSION: Since date fruit has shown no effect in acute phase of formalin test, tail flick and paw pressure so it can be concluded that ADFE has no central effects in decreasing pain. Considering the analgesic effect of ADFE on chronic phase of formalin test, it seems that the analgesic effect of ADFE is mainly peripheral and anti-inflammatory. Date fruit Antinociception Tail flick test Paw pressure test Rat 2008 1 01 7 12 http://jbums.org/article-1-2487-en.pdf
223-2488 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 VITAMIN E EFFECTS ON AFLATOXIN B1- INDUCED LIVER CELLS IN ALBINO NMRI MALE MICE MH Mirmomeni, A Amini, A Hosseinzadeh Colagar, F Omidi BACKGROUND AND OBJECTIVE: Aflatoxins (AFs) are the most dangerous to human health because of their highly toxic, carcinogenic, teratogenic, hepatotoxic and mutagenic characteristics. Aflatoxins consist of a group of approximately 20 related secondary fungal metabolites although only aflatoxins B1 (AFB1), AFB2, AFG1 and AFG2 with toxicity AFB1>AFG1>AFB2>AFG2 which are normally found in foods. AFB1 is considered to be major risk factors in the development of hepatocellular carcinoma in humans. The present study was carried out to determine the toxic effects of AFB1 on liver cells and restraining its effect using vitamin E (α-tocofrol).METHODS: In this experimental study, the AFB1 was extracted from aspergillus flavous fungus cultivated in synthetic SLS (Sodium lauryl sulfate) medium and silica gel thin-layer chromatography. Then 40μg AFB1, 2mg vitamin E, 40 μg AFB1+ 2mg vitamin E were dissolved in 0.2 ml olive oil (as a solvent), separately. These solutions fed to 50 young white Albino- NMRI mice (with weighing approximately 32-34 grams) which divided into 5 random groups including: control (0.2 ml water), dissolver (olive oil), Vit E, AFB1 and AFB1+Vit E, daily up to 30 days. In the 31st day, liver samples were prepared for microscopic studies. FINDINGS: There was an increasing in the size of liver cells, cell boundaries were indistinct, and some of the cells were destroyed. The sinusoid volume had decreased and in some case was completely undistinguishable. Furthermore the numbers of large nucleuses were more than small nucleuses. In cells with two nucleuses, the border between the 2 nucleuses was more often indistinct and had shown interference with each other or seemed to have incomplete cells division. The size of liver cells in the AFB1+Vit E group showed an increasing (1117.5±2.5 μm2) as compare to control group (1116.5±2 μm2). But this difference between AFB1 (1116±1.2 μm2) and AFB1+VitE groups were significant (p<0.01). CONCLUSION: Vitamin E acts as a reductive compound against the toxic effects of oxidant substance in foods such as AFB1 and its reductive effects concerning the hepatotoxicity of AFB1 is probably the result of NADPH-oxides gatherings and halt in the production of super oxides. Aflatoxin B1 Vitamin E α-tocofrol Liver cells Morphologic changes 2008 1 01 13 21 http://jbums.org/article-1-2488-en.pdf
223-2489 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 CHARACTERIZATION OF HEAT SHOCK PROTEINS IN BRUCELLA ABORTUS AND INTERACTION OF THESE PROTEINS WITH PATIENT AND CONTROL SERA R Rajabnia, N Amirmozaffari, F Ghazi, A Mostafazadeh A Mostafaie BACKGROUND AND OBJECTIVE: The bacteria begin to synthesize heat shock proteins (hsp) when facing elevated temperatures. Some of the hsps recognized during infection by host immune system. The goal of this study was to determine the synthetic pattern of hsps in brucella abortus that were subjected to different heat shocks and antigenecity of hsps in both patient and healthy sera by immuno blot assay.METHODS: In this experimental trial study, five brucella abortus were isolated from cows and were subjected to 39, 40, and 42ºC heat shocks. Then cell proteins were extracted and electrophoresis in polyacrylamide gels (SDS-PAGE) was performed. Finally antigenecity of hsps (hsp60) in healthy as well as patient sera were surveyed by immuno blot.FINDINGS: The major protein groups were in the range of 30-75 and 14-20 KDa in SDS-PAGE. The amounts of a 60 KDa protein band (hsp60) was significantly enhanced following heat shock as compared to the unheated cells. The sera from brucella patients reacted with several of these cell derived protein bands in immuno blots, none of which were reactive with sera from healthy individuals. The 60 KDa band was the most significant and showed strong reactions with all brucellosis sera samples. CONCLUSION: This study showed the brucella abortus produces heat shock proteins, especially hsp60, in response to heat shock. Brucellosis patient’s sera reacted strongly with these molecules. This observation points to the antigenecity properties of hsps, specially the overwhelming response to hsp-60. Therefore, probably the hsp60 can be an antigen candidate for ELISA test development as well as for engineering sub unit vaccine against brucella. Brucella abortus Heat shock proteins Brucellosis 2008 1 01 22 28 http://jbums.org/article-1-2489-en.pdf
223-2490 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 FREQUENCY RATE OF VASCULAR DEMENTIA AND ITS RELATIONSHIP WITH TOPOGRAPHY AND ETIOLOGY IN STROKE PATIENTS K Ghandehari HR Riasi BACKGROUND AND OBJECTIVE: Vascular dementia (VD) is a stroke complication which increases disability and dependency of the patients. This study was designed to evaluate the frequency rate of VD and its relationship with topography and etiology of stroke.METHODS: In this prospective study, consecutive ischemic stroke patients admitted in Valie-Asr hospital, Birjand, Iran, during 2006-2007. Diagnosis of ischemic stroke, its topography and etiology was made by neurologist based on the standard protocol. Ischemic VD was determined by DSMIV (diagnostic and statistical manual of mental disorders, fourth edition) criteria. Stroke etiology categorized as atherosclerotic, cardioembolic, miscellaneous, uncertain and mixed subtypes. VD was classified into cortical, subcortical and mixed subtypes.FINDINGS: Among 342 ischemic stroke patients, 21 patients (6.1%) had VD. Cortical, subcortical and mixed subtypes consisted 7, 7and 6 cases of VD topographies. VD was significantly more frequent in patients with simultaneous carotid and vertebrobasilar territories involvement, df=1, p<0.001. VD was found in 13.6% of patients with cardioembolic mechanism and 3.8% of other stroke patients which has a significant difference (df=1, p=0.001 OR=3.94).CONCLUSION: Vascular dementia is an infrequent complication of ischemic strokes. It is significantly more frequent in stroke patients with cardioembolic mechanism due to various territorial involvements. Dementia Brain Stroke 2008 1 01 29 33 http://jbums.org/article-1-2490-en.pdf
223-2491 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 EFFICACY OF AEROBIC EXERCISE IN THE TREATMENT OF MECHANICAL SHOULDER, LUMBAR AND KNEE PAIN SM Smailnejad Ganji, M Bahrami BACKGROUND AND OBJECTIVE: Mechanical shoulder, lumbar and knee pain is common on musculoskeletal system. Anti-inflammatory agents and physiotherapy are used for treatment of these conditions and unfortunately are unsuccessful. The purpose of this study was to assess the efficacy of aerobic exercise in the treatment of mechanical shoulder, lumbar and knee pain.METHODS: This semi- experimental study was conducted on 450 patients suffering from mechanical shoulder pain (150 patients), mechanical lumbar pain (150 patients) and mechanical knee pain (150 patients) referred to the clinic of orthopedics, Babol medical University from 2004 to 2006. All of these cases were educated to pain reduction or painless conditioning. Subjects were advised to do aerobic exercises such as swimming, running, walking and bicycling for one hour per day. They were followed at 2 month interval for 18 months. Cure rate in these three groups were compared.FINDINGS: The mean age of cases with shoulder, lumbar and knee pain was 36±22, 41±28 and 48±25 years, respectively. Duration of pain was 83±45, 93±80 and 48±30 days, respectively. Complete resolution of pain was seen in 80% of patients in shoulder group and in 88% of lumbar group and in 73.3% of knee group. Cure rate was significantly higher in patients suffered from spinal pain than to the other groups (p=0.03).CONCLUSION: The results showed that aerobic exercise is effective for treatment of mechanical pain. So establishing exercise program especially aerobic exercise should be considered as a way to prevent common musculoskeletal pains in community. Aerobic exercise Lumbar pain Shoulder pain Knee pain Mechanical pain 2008 1 01 34 38 http://jbums.org/article-1-2491-en.pdf
223-2492 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 RELATIONSHIP BETWEEN FETAL GENDER AND SOME PERINATAL COMPLICATIONS E Mobashery, H Khoddam L Shariati BACKGROUND AND OBJECTIVE: Recognition of risk factors which affected fetal health may be helpful in prevention, early diagnosis and treatment of irreversible fetal damages. Gender is a risk factor for many of fetal and neonatal problems. This study was performed to determine the relationship between fetal gender and some perinatal complications.METHODS: This is an analytical study which accomplished in 2004 based on existing data. The study population were 1600 newborns which born in Dezyani medical-educational centre of Gorgan. Based on including criteria, that is, being full term and singleton, absent of addiction or systemic diseases history of mothers during pregnancy, newborns records were studied. Fetal gender, fetal distress, 5th minute apgar score, delivery modes, amniotic fluid status and perinatal death were essential variables of this study.FINDINGS: Data analysis showed that 51% of newborns were male and male to female ratio was 1.04. From all newborns, 479 (29.94%) suffered from fetal distress and odds of female involvement was 1.13 times more than males (CI 95%=0.91-1.41, p<0.05). Mode of delivery in 37% of all were cesarean section and 53.37% of neonates were male (OR=1.72, CI 95%=1.04-2.85). Rate of cesarean due to fetal distress was more in pregnancies with male fetuses (p<0.05). In 206 (12.9%) of births, amniotic fluid was meconial and 108 (52.42%) of which were in pregnancies with female fetus.CONCLUSION: According to sex difference in some perinatal complications such as fetal distress, cesarean section delivery, consideration to fetal gender as a risk factor during prenatal and intrapartal management is suggested. Fetal gender/sex Perinatal complications Fetal distress 2008 1 01 39 43 http://jbums.org/article-1-2492-en.pdf
223-2493 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 FACTORS RELATED TO THE BIRTH OF CHILDREN WITH THALASSEMIA MAJOR IN BABOL DURING 1997-2006 SR Hosseini E Yaghoubi, M Ghanbari A Bijani BACKGROUND AND OBJECTIVE: The premarital screening of β-thalassemia was performed all over the county of Iran from 1997. Although this program can reduce the large number of children born with thalassemia, we are still witness to the birth of these children. The aim of this study was to survey the associated factors accompanied with the birth of children with thalassemia major in Babol, Iran during 1997-2006 in spite of this screening program.METHODS: This study was conducted on all parents of children with beta thalassemia major as case group and the carrier couples who had no child with thalassemia major as control group from 1997-2006. Data including age, sex, relations, insurance condition, screening condition, PND (prenatal diagnosis) condition, consultation and education about thalassemia were collected by a questionnaire and then analyzed.FINDINGS: Comparing two groups, the following results were obtained: being insured in control group was 5.6 (CI=2.3-13.8) times more than case group (p<0.001). Continuous care before pregnancy in control group was 95.8 times more than case group (OR=95.8, CI=18.5-496, p<0.001). Considering family relation there was not significant relationship between two groups. The trained couples in control group were 33 times more than case group (OR= 33, CI= 7-153, p<0.001). After bring all variables in logistic regression model, the most effect is related to the education about thalassemia, continuous cares and being insured, respectively (p<0.0001). CONCLUSION: The results of this study showed that education about thalassemia, continuous care after marriage, thalassemia consultations, and being insured are the important factors to decrease the birth rate of the children suffering from major thalassemia. β thalassemia major Prevention Factors 2008 1 01 44 49 http://jbums.org/article-1-2493-en.pdf
223-2494 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 PREVALENCE OF FLAT FOOT IN ELEMENTARY, GUIDANCE AND HIGH SCHOOL STUDENTS (BABOL 2005-2006) N Kamali, M. Haji Ahmadi, M Janmohammadi, AA Kamali BACKGROUND AND OBJECTIVE: Flat foot is a common problem for which the children visit the orthopedic clinic however it is not known exactly. Flat foot causes the feet tire easily and become achy after prolonged standing. There is controversy about its importance, prevalence and management. The aim of this study was to determine the prevalence of flat foot in elementary, guidance and high school students in Babol for educational year 2005-2006. METHODS: In this cross sectional study, foot prints of 1132 students (628 boys and 504 girls) between the ages of 6-18 years in four age groups of 6-8, 9-11, 12-14 and 15-18 years were recorded. FINDINGS: Among 1132 students, 134 (11.8%) had flat foot that 73 (11.6%) were boy and 61 (12.1%) were girl. Fifty nine (5.2%) had bilateral flat foot, 48 (4.2%) and 27 (2.4%) had right and left flat foot, respectively. The rate of prevalence of flat foot decreased with increasing age and with different oscillation in both sexes. CONCLUSION: With regard to the rate of prevalence of flat foot is high among students of Babol city, further studies related to factors such as obesity, prevalence of ligament laxity and wearing shoes are recommended. Flat foot Students Babol city 2008 1 01 50 54 http://jbums.org/article-1-2494-en.pdf
223-2495 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 PREVALENCE OF VENTRICULAR FIBRILLATION IN PATIENTS WITH ANTERIOR AMI AND RBBB IN SHAHID YAHYANEJAD HOSPITAL (BABOL 1997-2006) KH Amoozadeh Omrani A Mozaffarpour Noori BACKGROUND AND OBJECTIVE: Bundle branch block (BBB) early during acute myocardial infarction (AMI) is often considered high risk for mortality. Little is known about the prevalence of ventricular arrhythmia like ventricular fibrillation in the course of patients with anterior MI and right bundle branch block (RBBB). The aim of this study was to determine the prevalence of VF in patients with anterior AMI and RBBB in Shahid Yahyanejad hospital in Babol. METHODS: This cross sectional study was performed on 1000 patients’ files that admitted for acute MI in cardiac ward, CCU and emergency room in Shahid Yahyanejad hospital. Patients with Ant. MI and RBBB in electrocardiogram were entered the study. A questionnaire was filled out for every patient included age, sex, extension of MI, risk factors, presence or absence of VF and mortality were gathered and then data were analyzed.FINDINGS: From 1000 patients with acute MI, 47 had VF with RBBB. Mean age of patients with Ant MI, RBBB and VF was 56±10.34 years old and in patients without VF was 68.4±10.8 years old (p=0.013). Ventricular fibrillation in patients with Ant MI and RBBB was more common in men than women (p=0.047). None of patients with Ant. MI and RBBB with VF had hypertension, but 30.3% of patients with Ant. MI and RBBB without VF had HTN (p= 0.022). Mortality rate in patients with Ant. MI, RBBB and VF was 22.9% and in patients without VF was 6.1%, and it was statistically significant (p= 0.000).CONCLUSION: The results of this study showed that the prevalence of VF in patients with acute Ant MI and RBBB is more common in men than women and mortality rate of patients with ventricular fibrillation is significantly higher than patients without VF. Acute anterior myocardial infarction Right bundle branch block Ventricular fibrillation 2008 1 01 55 60 http://jbums.org/article-1-2495-en.pdf
223-2496 2024-03-29 10.1002
Journal of Babol University of Medical Sciences J Babol Univ Med Sci 1561-4107 2251-7170 10.22088/jbums 2008 9 6 COMMON POISONING EPISODES THE ROUTES OF SOLUTION WITH A VIEW OF POISONING IN MAZANDARAN PROVINCE PAST, PRESENT AND THE FUTURE A.A. Moghadamnia Poisoning is caused by deliberate or accidental exposure to potentially harmful drugs or chemicals. There are hundred thousands of deaths per annum from poisoning in the world.Accidental poisoning is most common in children and over 50 year old persons, but deliberate self-harm becomes predominant in teenage years and early adulthood. Understanding the patterns of poisoning can assist in developing suicide prevention strategies and reducing the risks of accidental poisoning. On the other hand, this could be helpful in reducing the accidental and occupational poisoning cases. Chemicals and synthetic drugs are introduced and entered in the markets annually. In some circumstances, many of these materials can potentially induce poisoning. In excessive amounts, substances that are usually harmless, even apparently safe drugs can cause poisoning. To reduce the morbidity and mortality and overall burden of poisoning in the community, consideration should be given to developing education program as an effective tool and establishing poison information centers. In this article the findings of more than one decade survey around the poisoning cases in Mazandaran province will be reviewed. Drug poisoning Chemical poisoning Accidental poisoning Deliberate self-harm Suicide Childhood poisoning 2008 1 01 61 77 http://jbums.org/article-1-2496-en.pdf