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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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article
Complications of Neonatal Jaundice and the Predisposing Factors in Newborns
H Boskabadi
1
F Ashrafzadeh
2
F Azarkish
3
A Khakshour
4
BACKGROUND AND
OBJECTIVE: Hyperbilirubinemia is one of the most common problems during the
neonatal period. Despite the severe complications of jaundice, no reliable data
is available regarding the prevalence of acute and chronic complications of
jaundice and the predisposing factors in our community. Therefore, this study
aimed to determine the
complications of neonatal jaundice and the predisposing factors in neonates.
METHODS: This cross-sectional study was performed on icteric,
term newborns with bilirubin level higher than 20 mg/dl, referring to Ghaem
Hospital during 2003-2013. After history taking and physical examinations,
developmental status of infants was followed within six and twelve months after
birth, using Denver Developmental Screening Test-II. The newborns were divided into two groups, based on the
occurrence or non-occurrence of complications (e.g., acute or chronic
kernicterus, auditory disorders and developmental disorders). Afterwards, predisposing factors for these complications were evaluated.
FINDINGS Complications of jaundice
were reported in 143 (13.37%) out of 1069 neonates. The two groups were
not significantly different in terms of variables such as neonatal age and gender or maternal
age. However, there was a significant difference between the children with and
withod complication regarding treatment modality and mean total serum bilirubin
level (27 mg/dl vs. 32 mg/dl) (p<0.05). The predisposing factors for
neonatal complications were as follows: idiopathic jaundice (30%), ABO
incompatibility (18%), Rh incompatibility (14.8%), G6PD deficiency (12.6%) and sepsis
(3.3%).
CONCLUSION: Our findings showed that
ABO incompatibility, Rh incompatibility and G6PD deficiency were the most common risk factors for jaundice, followed
by idiopathic jaundice.
http://jbums.org/article-1-5256-en.pdf
Kernicterus
Developmental Disorders
Hearing Loss
Jaundice
Hemolysis
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Journal of Babol University Of Medical Sciences
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Umbilical Cord Bilirubin Level as a Predictive Indicator of Neonatal Jaundice
Y Zahedpasha
1
M ahmadpour kacho
2
A Firoozjahi
3
A Dehvari
dehvari.abdh@yahoo.com
4
M Baleghi
5
T Jahangir
6
BACKGROUND AND OBJECTIVE: Neonatal jaundice is a major problem among infants in the
first weeks of life. Research on several indicators of severe neonatal jaundice
including alpha-fetoprotein and
umbilical cord bilirubin level has indicated contradictory results. Therefore,
the aim of the present study was to evaluate the significance of umbilical cord
bilirubin level as a predictive indicator of severe neonatal jaundice.
METHODS: This prospective,
cross-sectional study was performed on 102 healthy infants, born to healthy
mothers at Babol Clinic Hospital, Babol, Iran. After birth, 2 cc blood samples
were obtained from the umbilical cord and the bilirubin level was measured in
the hospital laboratory. The infants were followed-up after hospital discharge
in terms of jaundice presentations. In case jaundice was diagnosed in infants,
they were compared in treated and untreated groups.
FINDINGS: Clinical jaundice was not detected in 54 cases
(52.94%). Overall, 48 neonates (47.05%) suffered from clinical jaundice and 10
cases (8.9%) presented with severe jaundice, requiring treatment based on the
criteria proposed by the American Academy of Pediatrics (AAP). The mean
umbilical cord bilirubin level was 1.82±0.42 mg/dl in the untreated group and
2.36±0.56 mg/dl in the treated group (P=0.000). The area under the ROC curve
for umbilical cord bilirubin level was 0.722 in the treated group, based on the
AAP criteria. The cut-off point of 2 mg/dl showed 80% sensitivity and 73%
specificity in predicting severe jaundice (requiring treatment), based on the
AAP criteria.
CONCLUSION: As the results indicated, measurement of
umbilical cord bilirubin level and determination of a suitable cut-off point
could be valuable in predicting severe jaundice in newborns.
http://jbums.org/article-1-4804-en.pdf
Neonatal Jaundice
Umbilical Cord Blood
Bilirubin
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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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23
article
Clinical Findings of Arthroscopic Release in Treatment of Primary Frozen Shoulder
A Sadeghifar
sadeghifar@kmu.ac.ir
1
A Saeedi
2
M Daneshfar
daneshfar@yahoo.com
3
BACKGROUND AND OBJECTIVE: Frozen shoulder
is a common condition, characterized by pain and restrictions in shoulder
movements. Different non-surgical and surgical methods are used to overcome
this condition. Given the high prevalence of frozen shoulder among the working
class in communities, re-empowerment is essential for individuals’ return to daily activities. Considering the contradictory results reported by
previous research, further investigations are required in this area. Therefore,
this study aimed to evaluate the clinical findings of arthroscopic release in treatment
of primary frozen shoulder.
METHODS: This cross-sectional study was
performed on all patients with primary frozen shoulder, referring to Bahonar
and Shafa Hospitals of Kerman, Iran. These patients were candidates for surgery
due to unsuccessful supportive treatment. First, American Shoulder and Elbow
Surgeons (ASES) assessment form (score: 0-100) and Simple Shoulder
Test (a 12-item questionnaire) were completed before surgery. Then, all
patients underwent arthroscopic release and examinations. The assessment forms
were completed again within 3 and 12 months after surgery.
FINDINGS: Overall, 15
patients with the mean age of 50.57±12.01 years were included in this study.
There was a significant difference in the mean score of SST before (10.21±0.98)
and after (10.98±1.05) surgery (p=0.034). Also, patients’ performance at
12-month follow-up significantly improved, compared to the three-month
follow-up (p=0.014). There was a significant difference in the mean scores of
ASES test before and after surgery (p=0.007). Also, the mean score
of ASES test was higher at 12-month follow-up, compared to the three-month
follow-up (p=0.019).
CONCLUSION: Overall,
arthroscopic release could help relieve pain and improve
the range of shoulder movements in patients. Moreover, it could help patients return to their daily activities and regain their productivity. In fact, this technique facilitates
simultaneous diagnosis and treatment of shoulder joint problems.
http://jbums.org/article-1-5394-en.pdf
Frozen Shoulder
Arthroscopic Release
American Shoulder and Elbow Surgeons
Simple Shoulder Test
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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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The Study of the Frequency of Hypertensive Retinopathy in the Elderly at Amirkola Town During 2011-2012
S A Rasoulinejad
rasolisa2@gmail.com
1
E Mikanikey
2
S R Hosseini
3
R Zaboli
4
E Rasoulinejad
5
BACKGROUND AND OBJECTIVE: The risk of high blood
pressure increases to a great extend with increasing age which, in turn, raises
the risk of retinopathy. Given the high prevalence of ophthalmic complications
in the advanced ages, there is a growing need for public health and medical
services. This study aims to determine the frequency of hypertensive
retinopathy in the elderly, in Amirkola town.METHODS: This cross-sectional
study was performed on all patients aged 60 or above, residing in Amirkola town, Iran. All the patients
were referred to the eye clinic of Ayatollah Rouhani Hospital during 2011-2012.
Comprehensive ophthalmic examinations were performed by an ophthalmologist.
Based on the obtained definitive evidence and photographic findings, various
degrees of hypertensive retinopathy in one or both eyes were detected and
assessed.FINDINGS: Among the 505 studied
patients, 65 patients (12.9%) were suffering from hypertensive retinopathy.
About 10 (15.4%) patients were suffering from high blood pressure for more than
ten years. Moreover, 55 patients (84.6%) had hypertension for less than 10
years (p<0.0001). A total of 18 patients (27.7%) had history of
hyperlipidemia, while 47 patients (72.3%) had no history of it (p=0.005).
CONCLUSION: The obtained results of
our study indicated that the frequency of hypertensive retinopathy in the
elderly patients was high. Therefore, monitoring blood pressure and serum
lipids on a regular basis in the elderly is highly recommended.
http://jbums.org/article-1-5555-en.pdf
Elderly
Hypertension
Retinopathy
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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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The Frequency of Road Accident Injuries among Victims Admitted to Shahid Beheshti Hospital of Babol, Iran in 2010-2012
S.M Esmailnejad Ganji
1
M Bahrami
Drbahrami865@gmail.com
2
N Poorghaz
3
S Kamali Ahangar
4
BACKGROUND AND OBJECTIVE: Road
accidents are one of the major causes of mortality and severe injuries, which
impose substantial financial and social costs on communities. This study was
conducted to investigate the epidemiology of road traffic traumas to the upper
and lower extremities.
METHODS: In this cross-sectional study, victims,
admitted to Shahid Beheshti Hospital of Babol, Iran, were evaluated during
2010-2012. Demographic data, accident location, day, season and time of
accident, as well as admission time were investigated.
FINDINGS: In total, 1049 victims
with the mean age of 32.93±16.56 years were included in this study. Overall, 830 (79.1%)
and 219 (20%) victims were male and female, respectively. The majority of
accidents occurred on inter-urban roads (n=830, 35%) on week days (n=839,
72.5%). The highest frequency of accidents was reported in summer (n=311,
29.6%) between 13:30 pm and 19:30 pm. The longest interval between the accident
and hospital admission was 1-2 hours following the accident.
CONCLUSION: The results of this study showed that road
accidents were more frequent in certain hours and seasons of the year.
Therefore, recognition of local effective factors in accidents could be a
proper guide for authorities to promote accurate and effective health planning
http://jbums.org/article-1-5441-en.pdf
Road traffic accident
Trauma
Season
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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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article
A Study of Dentists’ Knowledge about Dental Radiology Principles
S Haghanifar
1
E Moudi
2
F Abesi
3
A Bijani
4
O Kazemi
omran.kazemi47@gmail.com
5
BACKGROUND AND OBJECTIVE: The use of dental radiography is inevitable in order for disease diagnosis, assessment and monitoring. Radiogeraphy is potentially harmful due to the use of ionizing radiation. This study was conducted to evaluate dentists’ knowledge about the principles of dental radiology.
METHODS: This cross-sectional study was performed on 600 general dentists willing to cooperate with this study in Amol, Noor, Mahmoodabad and Sari cities located in Mazandaran province, Iran, in 2014. All the data were obtained by means of a questionnaire. The questionnaire included two parts the first part surveyed demographic information, and the second part included 11 items about radiographic technique and equipments.
FINDINGS: 500 questionnaires were completed. Among the surveyed population, 335 (67%) and 165 (33%) dentists were male and female, respectively. The mean of practical experiences was 12.35±6.68 years. 469 dentists (93.8%) used the dental X-ray machine with digital timer and 404 dentist (80.8%) used the dental X-ray machine with long cone tube. Additionally, 470(94%) X-ray machine had round. Generally, 367 (73.4%) and 374 (74.8%) dentists used bisecting technique and E-speed films, respectively. Also, annual calibration of X-ray devices was suggested by 416 (83.2%) dentists.
CONCLUSION: According to our study, dentists’ knowledge about the dental radiography principles was fair.
http://jbums.org/article-1-5364-en.pdf
Dentist
Dental Radiography
Radiology
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The Diagnostic Value of Fine Needle Aspiration as Compared to Pathology Results in Diagnosis of Thyroid Nodules: A 22-Year Follow-up Study
S Siadati
pathbeheshti@yahoo.com
1
Z Moazezi
2
M A Bayani
3
A Mirzapour
4
N Nikbakhsh
pathbeheshti@yahoo.com
5
N Ghaemian
6
M Nabahati
7
S Shokri
8
M Sharbatdaran
9
BACKGROUND AND OBJECTIVE: Recently,
the efficiency of thyroid fine needle aspiration (FNA) as a method of choice in
evaluation and management of thyroid nodules has been questioned. The aim of this study was to determine the
diagnostic value of FNA as compared to pathology results in diagnosis of
thyroid nodules in Shahid Behashti Hospital of Babol, Iran, within 22 years.
METHODS: This
cross-sectional study was performed on cytology samples of 225 patients who
were undergoing thyroidectomy at Shahid Beheshti Hospital of Babol during
1990-2012. Patients’ age and gender, physician's experience in performing FNA,
type and location of surgery, FNA samples and pathology results were recorded.
According to the pathology reports, FNA results were divided into four groups
i.e. inadequate, benign, malignant and suspicious. The pathology results were
divided into benign and malignant groups. The results of both methods were
compared with each other.
FINDINGS: The
sensitivity and specificity of FNA in diagnosis of thyroid nodules were
60% and 96%, respectively. Also, its positive and negative predictive values
and diagnostic accuracy were 65%, 95% and 81.8%, respectively. Among the 225
cytology samples, 127 (56.7%), 47 (20.9%), 27 (12%) and 24 (10.7%) were benign,
suspicious, malignant, and inadequate, respectively. Additionally, pathology
results were benign and malignant in 150 (66.7%) and 75 (33.3%) patients,
respectively.
CONCLUSION: FNA was
comparatively effective in diagnosis of thyroid nodules.
http://jbums.org/article-1-5372-en.pdf
Fine Needle Aspiration
Thyroid
Pathology
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The Effects of Fenugreek Seed Powder on Oxidant and Antioxidant Factors in Male Rats with Acetaminophen-induced Liver Toxicity
A Mohammadzadeh
1
A Gol
agol@mail.uk.ac.ir
2
H Oloumi
3
BACKGROUND AND OBJECTIVE: Acetaminophen can induce liver damage via oxidative stress. This study aimed to evaluate the protective effects of fenugreek seed powder on oxidant and antioxidant factors in acetaminophen-induced liver toxicity.
METHODS: In this experimental study, 24 male Wistar rats, weighing 250-280 g, were divided into four groups: control, normal saline+fenugreek seed powder, acetaminophen and acetaminophen+fenugreek seed powder. After 24 h of fasting, groups Normal and Normal+ Fenugreek received normal saline and groups Acetaminophen and Acetaminophen + Fenugreek received 1000 mg/kg acetaminophen by gavage. After six hours, the normal saline and acetaminophen groups received normal saline, whereas the groups receiving normal saline+fenugreek powder and acetaminophen+fenugreek powder were administered 1000 mg/kg of fenugreek seed powder via gavage. Twelve hours after the second gavage, the rats were sacrificed and liver tissues were frozen and assessed.
FINDINGS: A decline in malondialdehyde and hydrogen peroxide levels was observed in group acetaminophen+fenugreek, compared to the acetaminophen group (0.2608±0.03 and 1.56±0.153 vs. 6.7±0.344 and 2.38±0.104 in acetaminophen groups p<0.001 and p<0.05, respectively). Also, the activities of peroxidase and catalase increased in these groups, compared to the acetaminophen groups (19.07± 3.366 and 1.174±0.242 vs. 8.108 ± 2.46 and 0.614±0.089 in acetaminophen groups, respectively).
CONCLUSION: The results of this study showed that fenugreek seeds could lead to reduced oxidative stress in acetaminophen-induced liver toxicity
http://jbums.org/article-1-5133-en.pdf
Acetaminophen
Fenugreek seeds
Liver
Oxidative stress
Rat
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Journal of Babol University Of Medical Sciences
Journal of Babol University of Medical Sciences
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An Evaluation the Effect of Glycyrrhetinic and Glycyrrhizic Acids Derived from Licorice Extract on Gastric Cancer Cell Lines
K Mahdinejadiani
1
H Shirzad
shirzadeh@yahoo.com
2
Sh Fakhari
3
A Jalili
4
BACKGROUND AND OBJECTIVE: Gastric cancer is the second most prevalent carcinogenic disease and surgery, chemotherapy and radiation are its principal treatment modalities. However, in most cases, poor response to treatment and adverse side effects are observed regarding these modalities. Given the lack of response to treatment and growing rates of gastric cancer, researchers are trying to come up with more efficient treatments with fewer side effects. In the traditional medicine, licorice has been suggested as a cancer treatment considering its high antioxidant properties and few side effects. This study aimed to evaluate the effect of licorice extract on gastric cancer cell lines.
METHODS: In this experimental study, adenocarcinoma gastric cell lines were prepared from cell bank and were cultured. After passage, the cells were transferred into a 96-well plate. In each well, approximately 2,000 cells in RPMI-1640 culture medium with FBS (10%) were placed. The cells were repeatedly exposed to different concentrations of Glycyrrhetinic acid (0, 1, 10 and100.1 ;muM) and Glycyrrhizic acid (10, 1, 100 and 0.1 ;muM) for 24 and 48 hours. Finally, the obtained results of the experimental and control groups were compared with each other.
FINDINGS: According to our results, the toxic effect of Glycyrrhetinic and Glycyrrhizic acids is dose and time dependent. In 24 hours, the mean optical density (MOD) in 100 ;muM concentration of Glycyrrhetinic acid was 0.41±0.02 and 0.79±0.04 in the experimental and control groups, respectively (p=0.0002). After 48 hours, MOD was 0.16±0.004 and 1.749±0.24 in the experimental and control groups, respectively (p=0.0003). Moreover, the MOD of 100 ;muM concentration of Glycyrrhizic acid was 0.78±0.53 and 2.09±0.49 in the experimental and control groups in 48 hours. There was a significant difference between the experimental and control groups (p=0.035).
CONCLUSION: The results of this study demonstrated that the licorice compounds have a toxic effect on carcinogenic cells. Therefore, it is recommended to perform more study on both Glycyrrhizic and Glycyrrhizic acids as effective compounds on gastric cancer treatment.
http://jbums.org/article-1-4756-en.pdf
Gastric Cancer
Glycyrrhetinic Acid
Glycyrrhizic Acid
Licorice
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Guideline for Writing and Reviewing of Medical Manuscripts for Publication in Scientific Journals
B Heidari
bheidari6@gmail.com
1
Publication of research articles is essential for academic success. Submitted papers to for publication require reviewing which usually is performed by researchers who are experienced in the field of the manuscript topic. The reviewing process is performed according to criteria which are almost similar for all journals and can be used for both preparation aswel as review of manuscript. The present study described the criteria which is usually necessary in preparing manuscript for publication in the most international scientific journals. Regarding the importance of research in providing scientific products, the present study was conducted to accustom young researchers particularly medical students and residents to medical writing. In particular these subjects can be also considered for reviewing of manuscripts.
http://jbums.org/article-1-5348-en.pdf
Writing Manuscript
Reviewing Manuscripts
Manuscript Publication