fa ارتباط شاخص های استرس اکسیداتیو نوزاد، مادران در مواجهه با انتونوکس ‏ مامایی Midwifery تحقیقی Research <p dir="rtl" style="margin: 0cm 0cm 0.0001pt text-align: right line-height: 13.05pt direction: rtl unicode-bidi: embed"><font size="2"><strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">سابقه و هدف</span></strong><span dir="ltr"></span><strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span>:</span></strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)">گاز انتونکس گازی بی بو و بی مزه بوده و اولین مادۀ بیهوشی است که در مامائی مورد استفاده قرار گرفته است. از آنجاییکه مطالعاتی در زمینه تاثیر این گاز روی استرس اکسیداتیو انجام نگرفته است. لذا این مطالعه به منظور بررسی ارتباط شاخص های استرس اکسیداتیو نورادان و مادران در مواجهه با انتونوکس در طی زایمان طبیعی انجام شد.</span><span dir="ltr" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)"><o:p /></span></font></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 13.05pt direction: rtl unicode-bidi: embed text-align: start"><font size="2"><strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">مواد و روشها</span></strong><span dir="ltr"></span><strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span>: </span></strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)">این مطالعه کوهورت بر روی 120 مادر در حال زایمان طبیعی در 2 گروه 60 نفره زایمان با و بدون استفاده از گاز بی دردی انتونوکس انجام شد. پس از زایمان از بندناف نوزادان مادران هر 2 گروه، 5 سی سی خون شریانی گرفته و شاخص های مالون دی الدئید، گروه های تیول و ظرفیت تام آنتی اکسیدانی اندازه گیری و مورد بررسی قرار گرفت.<o:p /></span></font></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 13.05pt direction: rtl unicode-bidi: embed text-align: start"><font size="2"><strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">یافته</span></strong><strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">­</span></strong><strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">ها</span></strong><span dir="ltr"></span><strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span>:</span></strong><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)">نتایج نشان داد که هیچکدام از شاخص های استرس اکسیداتیو شامل ظرفیت تام انتی اکسیدانی به ترتیب در گروه زایمان بدون انتونوکس و با انتونوکس 1/21±1/33  در مقابل 1/3±1/59 (0/84=</span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">p</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)"><span dir="rtl"></span>)، گروه های تیول 0/313±0/363  در مقابل 0/225±0/238 (0/07=</span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">p</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)"><span dir="rtl"></span>) لیپید پراکسید اکسیدانت 2/76±4/60 در مقابل 3/19±5/31 (1=</span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">p</span><span dir="rtl"></span><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: rgb(51, 51, 51)"><span dir="rtl"></span>) تفاوت معنی دار نداشتند.<o:p /></span></font></p> <p dir="rtl" style="color: rgb(51, 51, 51) font-family: Tahoma, Arial, Verdana line-height: 20.8px text-align: start"><font size="2"><strong style="line-height: 13.05pt color: rgb(0, 0, 0) font-family: Tahoma"><span lang="AR-SA" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">نتیجه گیری</span></strong><span dir="ltr"></span><strong style="line-height: 13.05pt color: rgb(0, 0, 0) font-family: Tahoma"><span dir="ltr" style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span>:</span></strong><span dir="rtl"></span><strong style="line-height: 13.05pt color: rgb(0, 0, 0) font-family: Tahoma"><span style="font-family: Tahoma, sans-serif color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="rtl"></span> </span></strong><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">نتایج مطالعه</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">نشان داد که مواجهه با گاز</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">انتونوکس</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">شاخص های استرس اکسیداتیو نوزاد را تغییر</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">نمی دهد</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span>. </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">لذا به نظر می رسد،</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">می توان از</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">انتونوکس</span><span dir="ltr"></span><span dir="ltr" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"><span dir="ltr"></span> </span><span lang="AR-SA" style="font-family: Tahoma, sans-serif background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">به عنوان یک روش بی خطر برای نوزاد در زایمان طبیعی استفاده کرد.</span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">BACKGROUND AND OBJECTIVE:</span></b><span style="font-size: 10pt"> Entonox is an odorless, tasteless gas and the first anesthesia agent used in obstetrics. To date, no studies have evaluated the effects of Entonox on oxidative stress. This study aimed to investigate the association between infant oxidative stress indices in mothers exposed to Entonox gas during vaginal delivery.</span><b><span style="font-size: 10pt color: blue"> </span></b><span style="font-size: 10pt"><o:p /></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">METHODS: </span></b><span style="font-size: 10pt">This cohort study was conducted on 120 pregnant women undergoing natural labor. Subjects were divided into two groups of delivery with and without exposure to analgesic Entonox (N=60). After delivery, 5 ml of arterial blood was obtained from the umbilical cords of all infants, and indicators such as malondialdehyde, thiols and total antioxidant capacity were measured and evaluated in each group.<o:p /></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">FINDINGS: </span></b><span style="font-size: 10pt">In this study, there were no significant differences in the indicators of oxidative stress between the study groups. Values obtained in groups with and without Entonox exposure were respectively as follows: total antioxidant capacity (1.33±1.21 vs. 1.59±1.3, p=0.84), thiols (0.363±0.313 vs. 0.238±0.225, p=0.07), lipid peroxidation (4.60±2.76 vs. 5.31±3.19, p=1).</span><span style="font-size: 10pt"> <o:p /></span></font></p> <font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">CONCLUSION:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">According to the results of this study, exposure to Entonox had no significant effects on the indicators of infant oxidative stress. Therefore, Entonox exposure could be used as a safe analgesic approach in natural delivery.</span></font> استرس اکسیداتیو, زایمان طبیعی, زایمان بی درد, نوزاد. Oxidative Stress, Natural Delivery, Painless Delivery, Infant 34 38 http://jbums.org/browse.php?a_code=A-10-1311-1&slc_lang=fa&sid=1 K Vakilian کتایون وکیلیان dr.kvakilian@arakmu.ac.ir 100319475328460011748 100319475328460011748 Yes A Ranjbar اکرم رنجبر 100319475328460011749 100319475328460011749 No