fa بررسی نقطه برش آنتی ژن اختصاصی پروستات (Prostatic Specific Antigen) در بیماران مراجعه کننده به بیمارستان شهید بهشتی بابل اورولوژی Urology مقطعی Cross Sectional <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 16pt direction: rtl unicode-bidi: embed"><strong><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: blue">سابقه و هدف:</span></strong><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: blue"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">سرطان پروستات شایع ترین نئوپلاسم در آقایان است. آنتی ژن اختصاصی پروستات که برای غربالگری سرطان پروستات مورد استفاده قرار می گیرد. تحت تاثیر عوامل مختلفی از جمله سن متغیر می باشد، لذا این مطالعه با هدف بررسی نقطه برش آنتی ژن اختصاصی پروستات (</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">PSA</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">=</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">Prostate-Specific</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">Antigen</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">) در بیماران با سرطان پروستات انجام شده است.</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)"><!--stripped--><!--stripped--></span></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 16pt direction: rtl unicode-bidi: embed"><strong><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: blue">مواد و روشها:</span></strong><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: blue"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">این مطالعه مقطعی بوده طی سه سال بر روی بیمارانی که تحت بیوپسی پروستات تشخیصی زیر گاید سونوگرافی ترانس رکتال قرار گرفتند، انجام شد. کلیه اطلاعات وارد چک لیست گردیده و مورد بررسی قرار گرفت.<!--stripped--><!--stripped--></span></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 16pt direction: rtl unicode-bidi: embed"><strong><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: blue">یافته­ ها:</span></strong><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">در مجموع 422 بیمار وارد مطالعه شدند. 180بیمار (42/7%) تشخیص آدنوکارسینوم و 242 بیمار (57/3%) دیگر هایپرپلازی خوش خیم پروستات (</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">BPH</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">) داشتند. میانگین سنی بیماران 9/62</span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">63/03 سال و میانگین آنتی ژن اختصاصی پروستات </span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">(64/44</span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">27/95 </span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">ng/mL</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">)</span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">بود. میانگین</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">PSA</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">در بیماران بیشتر از 51 سال 65/51</span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">28/66</span><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">ng/mL</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">که به طور معنی داری بیشتر از بیماران با سن کمتر از 50 سال بوده است (0/005=</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">p</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">).<!--stripped--><!--stripped--></span></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 16pt direction: rtl unicode-bidi: embed"><strong><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: blue">نتیجه</span></strong><span class="apple-converted-space"><b><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: blue"> </span></b></span><strong><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: blue">گیری:</span></strong><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">با توجه به نتایج مطالعه شانس ابتلا به سرطان پروستات در مردان با بازه سنی 80-60 سال بیشتر از سایرین می باشد. همچنین بیماران با</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">PSA</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">بین 20-10</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)">ng/mL</span><span class="apple-converted-space"><span lang="AR-SA" style="font-size: 10pt font-family: Cambria, serif color: rgb(51, 51, 51)"> </span></span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)">باید به طور کامل از لحاظ سرطان پروستات غربالگری شوند.<!--stripped--><!--stripped--></span></p> <p class="MsoNormal" dir="rtl" style="line-height: 16pt"><span dir="ltr"><!--stripped--> <!--stripped--></span></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">BACKGROUND AND OBJECTIVE:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">Prostate cancer is the most common form of malignancy among men.</span><span style="font-size: 10pt"> </span><span style="font-size: 10pt">Prostate-specific antigen (PSA) is used to screen for prostate cancer and may vary depending on different factors, such as age. This study aimed to investigate the cut-off value for </span><span style="font-size: 10pt">PSA in patients diagnosed with prostate cancer.</span><span style="font-size: 10pt"><!--stripped--><!--stripped--></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">METHODS:</span></b><span style="font-size: 10pt"> This cross-sectional study was conducted on patients with prostate biopsy diagnosis undergoing transrectal ultrasound during 2011-2014. Data collection was performed using prepared checklists.<!--stripped--><!--stripped--></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">FINDINGS:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">In total, 422 patients were enrolled in this study, 180 of whom (42.7%) were diagnosed with adenocarcinoma, and 242 (57.3%) had benign prostatic hyperplasia (BPH). Mean age of the patients was 63.03<span dir="rtl" lang="FA">±</span>9.62 years, and the mean PSA was 27.95<span dir="rtl" lang="FA">±</span>64.44 ng/ml. The mean of PSA in patients over 51 years was 28.66<span dir="rtl" lang="FA">±</span>65.51 ng/ml, which was significantly higher than the values of the patients under 50 years of age (p=0.005).</span><span dir="rtl" lang="AR-SA" style="font-size: 10pt"><!--stripped--><!--stripped--></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">CONCLUSION:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">According to the results of this study, the risk of prostate cancer was higher in the men within the age range of 60-80 years. In addition, patients with PSA levels of 10-20 ng/mL need to be fully screened for prostate cancer</span></font><span style="font-size: 10pt"><font face="times new roman, times, serif">.</font><!--stripped--><!--stripped--></span></p> سرطان پروستات, آنتی ژن اختصاصی پروستات, آدنوکارسینوم, بیوپسی سوزنی Prostate Cancer, Prostate-Specific Antigen, Adenocarcinoma, Needle Biopsy 14 18 http://jbums.org/browse.php?a_code=A-10-1774-1&slc_lang=fa&sid=1 H Shafi حمید شافی neda_amani69@yahoo.com 100319475328460012431 100319475328460012431 No AA Kasaeeyan علی اکبر کسائیان 100319475328460012432 100319475328460012432 Yes A Khakpoor احمد خاکپور 100319475328460012433 100319475328460012433 No F Karimi فهیمه کریمی 100319475328460012434 100319475328460012434 No N Amani ندا امانی 100319475328460012435 100319475328460012435 No