fa اثر تمرین اختیاری و عصاره گیاه مریم‏گلی بر آسیب های بافت پانکراس موش های صحرایی مسموم شده با دیازینون فیزیولوژی ورزشی Sport Physiology تجربی Experimental <p dir="rtl" style="margin: 0cm 0cm 0.0001pt text-align: right line-height: 15.6pt direction: rtl unicode-bidi: embed"><font face="times new roman, times, serif"><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">سابقه و هدف</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">:</span></strong><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> </span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">استرس اکسیداتیو شایع ترین اثر دیازینون بر موجودات زنده می باشد که سبب اختلال در عملکرد و تخریب بافت پانکراس می شود. در این مطالعه اثر عصاره گیاه مریم گلی همراه با تمرین اختیاری بر تغییرات بافتی پانکراس در موش های مسموم شده با دیازینون مورد بررسی قرار گرفت.</span><span dir="ltr" style="font-size: 10pt color: rgb(51, 51, 51)"><!--stripped--><!--stripped--></span></font></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 15.6pt direction: rtl unicode-bidi: embed text-align: start"><font face="times new roman, times, serif"><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">مواد و روشها</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">:</span></strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"> </span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">در این مطالعه آزمایشگاهی، 35 سر موش صحرایی نر نژاد ویستار به پنج گروه 7 تایی کنترل، دیازینون، دیازینون-عصاره، تمرین-دیازینون، تمرین- عصاره</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">–</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> دیازینون تقسیم شدند. گروه های تمرینی به مدت 4 هفته بر روی چرخ دوار به تمرین پرداختند. به حیوانات در گروههای آزمایشی، دیازینون با دوز 200 میلی گرم بر کیلوگرم برای یکبار در طول دوره و عصاره با دوز 100میلی گرم بر کیلوگرم به مدت چهار هفته (پنج روز در هفته) به صورت داخل صفاقی تزریق گردید. موش ها 24 ساعت بعد از آخرین تزریق کشته شدند. برش‏های بافتی از پانکراس جهت مطالعات میکروسکوپی تهیه شد.<!--stripped--><!--stripped--></span></font></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 15.6pt direction: rtl unicode-bidi: embed text-align: start"><font face="times new roman, times, serif"><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">یافته</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">­</span></strong><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">ها</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">:</span></strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"> </span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">تعداد (0/67</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">4/32) و قطر (1/01</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">15/84) جزایر لانگرهانس و تعداد سلول‏های آسینی(4/01</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">47/32) در گروه دیازینون کاهش معنی ‏داری نسبت به گروه کنترل (به ترتیب 38/1</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">6/44 و 1/2</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">16/17و 7/06</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">±</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">50) نشان داد(0/05</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> </span><span dir="ltr" style="font-size: 9pt background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">p<</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">). اما افزایش معنی داری بین پارامترهای مورد بررسی در گروه های دیازینون-عصاره، تمرین-دیازینون، تمرین- عصاره</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">–</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> دیازینون نسبت به گروه دیازینون مشاهده گردید(0/05</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> </span><span dir="ltr" style="font-size: 9pt background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">p<</span><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)">).<!--stripped--><!--stripped--></span></font></p> <p dir="rtl" style="color: rgb(51, 51, 51) font-size: 13px line-height: 20.7999992370605px text-align: start"></p> <p dir="rtl" style="margin: 0cm 0cm 0.0001pt line-height: 15.6pt direction: rtl unicode-bidi: embed text-align: start"><font face="times new roman, times, serif"><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">نتیجه</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial"> </span></strong><strong><span lang="AR-SA" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">گیری</span></strong><strong><span dir="ltr" style="font-size: 9pt color: blue background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">:</span></strong><span lang="AR-SA" style="font-size: 10pt color: rgb(51, 51, 51)"> </span><span lang="AR-SA" style="font-size: 9pt background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">یافته‏ های این مطالعه نشان داد که عصاره مریم‏ گلی و تمرین اختیاری آسیب های بافت پانکراس ناشی از تزریق دیازینون را کاهش می دهد</span><span dir="ltr" style="font-size: 9pt background-image: initial background-attachment: initial background-size: initial background-origin: initial background-clip: initial background-position: initial background-repeat: initial">.</span></font><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra' color: rgb(51, 51, 51)"><!--stripped--><!--stripped--></span></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">BACKGROUND AND OBJECTIVE:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">Oxidative stress is the most common effect of diazinon on living organisms, which leads to the dysfunction and destruction of pancreatic tissues. In this study, we evaluated the effects of Salvia officinalis extracts and optional exercise on histological changes of the pancreas in rats poisoned by diazinon</span><span class="hps"><span lang="EN" style="font-size: 10pt">.</span></span><span class="shorttext"><span style="font-size: 10pt"><!--stripped--><!--stripped--></span></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">METHODS:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">In this laboratory study, 35 male Wistar rats were divided into five groups, each consisting of seven rats: control, diazinon, diazinon-extract, exercise-extract and exercise-extract-diazinon groups. The exercise groups practiced on a spinning wheel for four weeks. The rats in the experimental groups received 200 mg of diazinon intraperitoneally once during the intervention. In addition, they received 100 mg of the extract for four weeks (five days a week). The rats were sacrificed 24 hours after the final injection. Pancreatic tissue sections were prepared for microscopic studies<span class="shorttext">.  <!--stripped--><!--stripped--></span></span></font></p> <p class="MsoNormal" style="line-height: 16pt direction: ltr unicode-bidi: embed"><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">FINDINGS:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">The number (4.32<span dir="rtl" lang="FA">±</span>0.67) and diameter (15.84<span dir="rtl" lang="FA">±</span>1.01)</span><span style="font-size: 10pt"> </span><span style="font-size: 10pt">of the islets of Langerhans and the number of acinar cells (47.32<span dir="rtl" lang="FA">±</span>4.01) in the diazinon group showed a significant reduction, compared to the control group (6.44<span dir="rtl" lang="FA">±</span>1.38, 16.17<span dir="rtl" lang="FA">±</span>1.2 and 50<span dir="rtl" lang="FA">±</span>7.06, respectively) (p<0.05). However, a significant increase was observed in the evaluated parameters in diazinon-extract, exercise-extract and exercise-extract-diazinon groups, compared to the diazinon group </span><span style="font-size: 10pt">(p<0.05)</span><span style="font-size: 10pt">. <!--stripped--><!--stripped--></span></font></p> <p><font face="times new roman, times, serif"><b><span style="font-size: 10pt color: blue">CONCLUSION:</span></b><span style="font-size: 10pt"> </span><span style="font-size: 10pt">The findings of this study indicated that Salvia officinalis extracts and optional exercise could reduce pancreatic tissue damages, induced by diazinon injection</span></font></p> مریم‏گلی, دیازینون, پانکراس, تمرین اختیاری Salvia Officinalis, Diazinon, Pancreas, Optional Exercise 48 54 http://jbums.org/browse.php?a_code=A-10-1674-2&slc_lang=fa&sid=1 E fattahi اسماعیل فتاحی esmail_fattahy@yahoo.com 100319475328460012916 100319475328460012916 Yes A Khoskafa آنا خشکفا 100319475328460012917 100319475328460012917 No