fa نقش سایتوکینها در ایجاد زایمان زودرس بیوشیمی Biochemical تحقیقی Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt text-justify: kashida text-kashida: 0% mso-line-height-rule: exactly" dir="rtl"><font size="2"><b><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt">سابقه و هدف:</span></b><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"> </span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">پاسخهای سیستم ایمنی مادر در طی حاملگی از جمله مهمترین فاکتورهای مورد نیاز جهت یک حاملگی موفق می باشد. اما در صورت تغییرات در این <a name="OLE_LINK2"></a><a name="OLE_LINK1"><span style="mso-bookmark: OLE_LINK2"><font face="Times New Roman">پاسخها روند طبیعی </font></span></a>و معمول حاملگی نیز دچار اختلال می شود. سایتوکینها مهمترین اجزاء سیستم ایمنی بوده که نشانگر افزایش و یا کاهش پاسخهای ایمنی می باشند. بنابراین بررسی الگوی سایتوکینها در طی زایمان زودرس می تواند جهت مشخص شدن پاتوژنز بیماری کمک کننده باشد. از اینرو هدف از انجام این مطالعه مروری، جمع آوری مطالعات اخیر در زمینه الگوی سایتوکینهای التهابی و ضد التهابی در طی زایمان زودرس می باشد.</span><b><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><o:p /></span></b></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt text-justify: kashida text-kashida: 0% mso-line-height-rule: exactly" dir="rtl"><font size="2"><b><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt">مواد و روشها:</span></b><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"> </span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial">برای انجام این مطالعه و دسترسی به داده های موجود واژه های سایتوکین، زایمان، زایمان زودرس و التهاب در موتورهای جستجوگر </span><font face="Times New Roman"><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">Pubmed</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">scopous</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">Google scholar</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span>، </span><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">Iranmedex</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span> و </span><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">Magiran</span><span dir="rtl"></span><span dir="rtl"></span><span style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"><span dir="rtl"></span><span dir="rtl"></span> <span lang="FA">مورد بررسی قرار گرفت.</span></span><b><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><o:p /></span></b></font></font></p><font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt mso-line-height-rule: exactly" dir="rtl"><font size="2"><b><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt">یافته ها:</span></b><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"> </span></font><a name="OLE_LINK4"></a><a name="OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"><font size="2">نتایج این بررسی نشان داد که مادران با </font></span></span></a><font size="2"><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt">زایمان زودرس و نوزادانشان از یک التهاب مزمن رنج می برند و در این میان دو سایتوکین </span></span></span><font face="Times New Roman"><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">IL-6</span></span></span><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span> و </span></span></span><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "2 Mitra"" dir="ltr">IL-10</span></span></span></font><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><span dir="rtl"></span><span dir="rtl"></span> از</span></span></span><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt mso-ascii-font-family: Arial mso-hansi-font-family: Arial"> جمله مهمترین سایتوکینهای درگیر در زایمان زودرس می باشند.</span></span></span><span style="mso-bookmark: OLE_LINK3"><span style="mso-bookmark: OLE_LINK4"><span lang="FA" style="font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"> </span></span></span><span lang="FA" style="color: blue font-family: "2 Mitra" mso-bidi-font-size: 10.0pt"><o:p /></span></font></p><font face="Times New Roman"><font size="3"> </font><b><span lang="FA" style="color: blue font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">نتیجه گیری:</span></b><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"> </span><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: Arial mso-hansi-font-family: Arial mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">با توجه به نتایج به دست آمده به نظر می رسد که افزا</span><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl">یش </span><span style="font-family: "Times New Roman","serif" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "2 Mitra" mso-bidi-language: FA mso-no-proof: yes mso-ansi-language: EN-US mso-fareast-language: EN-US">IL-6</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> و کاهش </span><span style="font-family: "Times New Roman","serif" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "2 Mitra" mso-bidi-language: FA mso-no-proof: yes mso-ansi-language: EN-US mso-fareast-language: EN-US">IL-10</span><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"><span dir="rtl"></span><span dir="rtl"></span> می تواند</span><span lang="FA" style="font-family: "2 Mitra" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-bidi-language: FA mso-no-proof: yes mso-ascii-font-family: Arial mso-hansi-font-family: Arial mso-ansi-language: EN-US mso-fareast-language: EN-US" dir="rtl"> به عنوان یک عامل مهم در ایجاد زایمان زودرس مطرح باشد.</span></font> <p><font face="Times New Roman" size="3"> </font></p><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt unicode-bidi: embed direction: ltr mso-line-height-rule: exactly"><font size="2"><font face="Times New Roman"><b><span style="color: blue mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman"">BACKGROUND AND OBJECTIVE:</span></b><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman""> Maternal immune responses are the important factors for a successful pregnancy. The normal pregnancy will be affected if the maternal immune responses are changed. Cytokines are the main immunological agents which display either elevated or declined immune responses. Therefore, assessment of cytokine pattern can be helpful for clarifying the main mechanisms of preterm delivery. Therefore, the main of this review article was to collect recent information regarding inflammatory and anti-inflammatory cytokine patterns in preterm delivery. <span style="color: rgb(79, 129, 189)"><o:p /></span></span></font></font></p><p><font face="Times New Roman" size="3"> </font></p><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt unicode-bidi: embed direction: ltr mso-line-height-rule: exactly tab-stops: 147.75pt"><font size="2"><font face="Times New Roman"><b><span style="color: blue mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman"">METHODS:</span></b><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman""> In order to perform this study and found the recent data, the key words including cytokines, delivery, preterm delivery and inflammation was searched using the common motor searches (PubMed, Scopus, Google Scholar, Iranmedex and Magiran).<o:p /></span></font></font></p><p><font face="Times New Roman" size="3"> </font></p><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt unicode-bidi: embed direction: ltr mso-line-height-rule: exactly"><font face="Times New Roman"><b><span style="color: blue mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman""><font size="2">FINDINGS:</font></span></b><span style="font-size: 14pt mso-bidi-font-family: "Times New Roman""> </span><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman""><font size="2">The results of this study showed that the mothers with preterm delivery and their neonates have suffered from a chronic inflammation and both IL-6 and IL-10 are the main involved cytokine in preterm delivery.<o:p /></font></span></font></p><p><font face="Times New Roman" size="3"> </font></p><p class="MsoNormal" style="margin: 0in 0in 0pt text-align: justify line-height: 16pt unicode-bidi: embed direction: ltr mso-line-height-rule: exactly"><font size="2"><font face="Times New Roman"><b><span style="color: blue mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman"">CONCLUSION:</span></b><span style="mso-bidi-font-size: 10.0pt mso-bidi-font-family: "Times New Roman""> Based on the results of the collected data it seems that increased IL-6 and decreased IL-10 can be considered as important factors in inducing preterm delivery.<o:p /></span></font></font></p><p><font face="Times New Roman" size="3"> </font></p> زایمان زودرس, التهاب, سایتوکین, سیستم ایمنی Cytokines, Preterm delivery, Inflammation, Immune system. 55 64 http://jbums.org/browse.php?a_code=A-10-1370-1001&slc_lang=fa&sid=1 F. Kamiab (BSc) فاطمه کامیاب 10031947532846006264 10031947532846006264 No گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز M. Tadaion (MSc) میترا تدین 10031947532846006265 10031947532846006265 No گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز P. Afshari (MSc) پوراندخت افشاری 10031947532846006266 10031947532846006266 No گروه مامایی، دانشکده پرستاری و مامایی، دانشگاه علوم پزشکی جندی شاپور اهواز M. Kazemi Arababadi (PhD) محمد کاظمی عرب آبادی 10031947532846006267 10031947532846006267 Yes مرکز تحقیقات ایمونولوژی بیماریهای عفونی، دانشگاه علوم پزشکی رفسنجان