fa اثر مکمل امگا-3 بر سطح سرمی پروفایل لیپیدی، آدیپوسایتوکین ها و شاخص التهاب عروقی در بیماران مبتلا به انفارکتوس میوکارد تغذیه Nutrition تحقیقی Research <p class="MsoNormal" dir="rtl" style="line-height: 16pt"><b><span style="font-size: 10pt font-family: '2 Mitra' color: blue">سابقه و هدف</span></b><b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra' color: blue">:</span></b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><a name="OLE_LINK135"></a><a name="OLE_LINK136"><span style="font-size: 10pt font-family: '2 Mitra'">تغییرات واسطه های التهابی نقش مهمی در انفارکتوس میوکارد دارند</span></a><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">. از آنجائیکه</span><span style="font-size: 10pt font-family: '2 Mitra'"> اثرات ضد التهابی </span><span style="font-size: 10pt font-family: '2 Mitra'">اسیدهای چرب امگا-3</span><span style="font-size: 10pt font-family: '2 Mitra'"> در بیماری های قلبی-عروقی گزارش شده است</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">، این</span><span style="font-size: 10pt font-family: '2 Mitra'"> مطالعه </span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">به منظور </span><span style="font-size: 10pt font-family: '2 Mitra'">بررسی اثر امگا-3 بر </span><span style="font-size: 10pt font-family: '2 Mitra'">سطح سرمی پروفایل لیپیدی، لپتین، آدیپونکتین و </span><span dir="ltr" style="font-size: 10pt font-family: 'Times New Roman', serif">E-selectin</span><span style="font-size: 10pt font-family: '2 Mitra'"> </span><span style="font-size: 10pt font-family: '2 Mitra'">در بیماران مبتلا به انفارکتوس میوکارد انجام شد.</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'"><!--stripped--><!--stripped--></span></p> <p class="MsoNormal" dir="rtl" style="line-height: 16pt"><b><span style="font-size: 10pt font-family: '2 Mitra' color: blue">مواد و روشها</span></b><b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra' color: blue">:</span></b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><span style="font-size: 10pt font-family: '2 Mitra'">در این مطالعه کارآزمایی بالینی دو سوکور 42</span><span style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><span style="font-size: 10pt font-family: '2 Mitra'">بیمار مبتلا به انفارکتوس میوکارد، به صورت تصادفی به دو گروه مداخله و کنترل تقسیم شدند. گروه مداخله روزانه 3</span><span style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><span style="font-size: 10pt font-family: '2 Mitra'">عدد کپسول 1 گرمی امگا-3 و گروه کنترل روزانه 3</span><span style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><span style="font-size: 10pt font-family: '2 Mitra'">عدد کپسول 1 گرمی پلاسبو (پارافین) به مدت 10 هفته مصرف کردند. غلظت سرمی </span><span style="font-size: 10pt font-family: '2 Mitra'">پروفایل لیپیدی، لپتین، آدیپونکتین و </span><span dir="ltr" style="font-size: 10pt font-family: 'Times New Roman', serif">E-selectin</span><span style="font-size: 10pt font-family: '2 Mitra'"> </span><span style="font-size: 10pt font-family: '2 Mitra'">در ابتدا و انتهای مداخله اندازه گیری </span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">و مقایسه شد</span><span style="font-size: 10pt font-family: '2 Mitra'">.&nbsp;</span><span style="font-family: 'Times New Roman', serif font-size: 10pt">IRCT=2021070410181N1</span></p> <p class="MsoNormal" dir="rtl" style="line-height: 16pt"><b><span style="font-size: 10pt font-family: '2 Mitra' color: blue">یافته&shy;ها</span></b><b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra' color: blue">: </span></b><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">در پایان مطالعه دریافت </span><span style="font-size: 10pt font-family: '2 Mitra'">مکمل امگا-3 </span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">در مقایسه با دارونما </span><span style="font-size: 10pt font-family: '2 Mitra'">موجب <a name="OLE_LINK112"></a><a name="OLE_LINK111">کاهش معنی دار سطح سرمی تری گلیسرید</a></span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'"> (</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">53/24</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">120/04 در مقابل48/84</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">150/76، 0/021</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">=</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">p</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">)</span><span style="font-size: 10pt font-family: '2 Mitra'"> لپتین</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'"> (</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">2/71</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">6/92 درمقابل 2/66</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">9/50، 0/007</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">=</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">p</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">) </span><span style="font-size: 10pt font-family: '2 Mitra'">و </span><span dir="ltr" lang="X-NONE" style="font-size: 10pt font-family: 'Times New Roman', serif">E-selectin</span><span lang="X-NONE" style="font-size: 10pt font-family: '2 Mitra'"> </span><span style="font-size: 10pt font-family: '2 Mitra'">(</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">10/04</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">20/98 در مقابل 12/58</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">27/06، 0/011</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">=</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">p</span><span style="font-size: 10pt font-family: '2 Mitra'">) </span><span style="font-size: 10pt font-family: '2 Mitra'">و افزایش معنی دار سطح سرمی آدیپونکتین </span><span style="font-size: 10pt font-family: '2 Mitra'">(</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">3/50</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">7/24 در مقابل 4/12</span><span lang="FA" style="font-size: 9pt font-family: 'Times New Roman', serif">&plusmn;</span><span lang="FA" style="font-size: 9pt font-family: '2 Mitra'">6/55، 0/026</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">=</span><span dir="ltr" style="font-size: 9pt font-family: 'Times New Roman', serif">p</span><span style="font-size: 10pt font-family: '2 Mitra'">)</span><span style="font-size: 10pt font-family: '2 Mitra'">&nbsp;</span><span style="font-size: 10pt font-family: '2 Mitra'">در بیماران مبتلا به انفارکتوس میوکارد شد. </span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">در هر دو گروه،</span><span style="font-size: 10pt font-family: '2 Mitra'"> بهبود سایر لیپیدهای خون (</span><span dir="ltr" style="font-size: 10pt font-family: 'Times New Roman', serif">TC, LDL-c, HDL-c</span><span style="font-size: 10pt font-family: '2 Mitra'">) نیز در مقایسه با مقادیر اولیه مشاهده گردید</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'"> (0/05></span><span dir="ltr" style="font-size: 10pt font-family: 'Times New Roman', serif">p</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'">)</span><span lang="AR-SA" style="font-size: 10pt font-family: '2 Mitra'">؛</span><span style="font-size: 10pt font-family: '2 Mitra'"> اما تفاوت بین دو گروه مکمل و دارونما از نظر آماری معنی دار نبود.</span><span lang="FA" style="font-size: 10pt font-family: '2 Mitra'"><!--stripped--><!--stripped--></span></p> <p align="left" class="MsoNormal" dir="rtl" style="text-align: right"><b><span lang="FA" style="font-family: '2 Mitra' color: blue">نتیجه</span></b><b><span dir="ltr" lang="FA" style="color: blue"> </span></b><b><span lang="FA" style="font-family: '2 Mitra' color: blue">گیری:</span></b><span lang="FA" style="font-family: '2 Mitra'">&nbsp;</span><span lang="FA" style="font-family: '2 Mitra'">نتایج مطالعه نشان داد که </span><span lang="FA" style="font-family: '2 Mitra'">دریافت روزانه مکمل امگا-3 می تواند </span><span lang="FA" style="font-family: '2 Mitra'">در تعدیل فاکتورهای التهابی </span><span lang="FA" style="font-family: '2 Mitra'">در بیماران مبتلا به انفارکتوس میوکارد مؤثر باشد.</span></p> <p class="MsoNormal" dir="rtl" style="line-height: 16pt"></p> <p class="MsoNormal" style="line-height: 15pt direction: ltr unicode-bidi: embed"><b><span style="font-size: 10pt font-family: 'Times New Roman', serif color: blue">BACKGROUND AND OBJECTIVE:</span></b><span style="font-size: 10pt font-family: 'Times New Roman', serif"> Changes in inflammatory mediators have an important role in myocardial infraction. Since the anti-inflammatory effects of Omega-3 fatty acids on cardiovascular diseases was reported, this study was done to evaluate the Omega-3 effect on serum lipid profile, leptin, adiponectin, and E-selectin in patients with myocardial infraction.</span><span style="font-size: 10pt font-family: 'Times New Roman', serif"><!--stripped--><!--stripped--></span></p> <p class="MsoNormal" style="line-height: 15pt direction: ltr unicode-bidi: embed"><b><span style="font-size: 10pt font-family: 'Times New Roman', serif color: blue">METHODS:</span></b><span style="font-size: 10pt font-family: 'Times New Roman', serif"> In this double blinded clinical trial study, 42 patients with myocardial infraction were randomly divided into two mediator and control group. For 10 weeks, the mediator group received 3 capsules of 1 gram Omega-3 daily, and the control group received 3 capsules of placebo (paraffin) daily. Concentration of serum lipid profile, leptin, adiponectin, and E-selectin was measured and compared at the beginning and at the end of the test. IRCT=2021070410181N1<!--stripped--><!--stripped--></span></p> <p class="MsoNormal" style="line-height: 15pt direction: ltr unicode-bidi: embed"><b><span style="font-size: 10pt font-family: 'Times New Roman', serif color: blue">FINDINGS:</span></b><span style="font-size: 10pt font-family: 'Times New Roman', serif">&nbsp;</span><span style="font-size: 10pt font-family: 'Times New Roman', serif">At the end of the study, after comparing the Omega-3 receiving group with placebo group, there was a significant decrease of serum level of triglyceride (120.04</span><span dir="rtl" lang="FA" style="font-size: 10pt font-family: 'Times New Roman', serif">&plusmn;</span><span style="font-size: 10pt font-family: 'Times New Roman', serif">53.24 versus 150.76<span dir="rtl" lang="FA">&plusmn;</span>48.84, p=0.021), leptin (6.92<span dir="rtl" lang="FA">&plusmn;</span>2.71 versus 9.05<span dir="rtl" lang="FA">&plusmn;</span>2.66, p=0.007), and E-selectin (20.98<span dir="rtl" lang="FA">&plusmn;</span>10.04 versus 6.55<span dir="rtl" lang="FA">&plusmn;</span>4.12), and there was a significant increase in the serum level of </span><span style="font-size: 10pt font-family: 'Times New Roman', serif">adiponectin (7.24</span><span dir="rtl" lang="FA" style="font-size: 10pt font-family: 'Times New Roman', serif">&plusmn;</span><span style="font-size: 10pt font-family: 'Times New Roman', serif">3.50 versus 6.55<span dir="rtl" lang="FA">&plusmn;</span>4.12, p=0.026) in patients with myocardial infraction. In both groups, improvement in the size of blood lipids (TC, LDL-C, HDL-C) was obvious when compared to the primary sizes (p<0.05) but the difference between the two complementary and placebo group was not statistically significant.<!--stripped--><!--stripped--></span></p> <p align="left" style="direction: ltr"></p> <p class="MsoNormal" style="line-height: 15pt direction: ltr unicode-bidi: embed"><b><span style="font-size: 10pt font-family: 'Times New Roman', serif color: blue">CONCLUSION:</span></b><span style="font-size: 10pt font-family: 'Times New Roman', serif"> T</span><span style="font-size: 10pt font-family: 'Times New Roman', serif">he results show that receiving Omega-3 on a daily basis can modulate inflammatory factors in patients with myocardial infraction.</span><span style="font-size: 10pt font-family: 'Times New Roman', serif"> <!--stripped--><!--stripped--></span></p> امگا-3, انفارکتوس میوکارد, آدیپونکتین, لپتین, E-selectin, پروفایل لیپیدی Omega-3, Myocardial Infraction, Adiponectin, Leptin, E-selectin, Lipid Profile 7 17 http://jbums.org/browse.php?a_code=A-10-1413-1&slc_lang=fa&sid=1 Fatemeh Haidari فاطمه حیدری haidari58@gmail.com 100319475328460013846 100319475328460013846 No Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran علوم پزشکی اهواز Mahshid Tavakoli مهشید توکلی mahshid218@yahoo.com 100319475328460013847 100319475328460013847 No Student Research Committee, Arvand International Division, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran دانشگاه علوم پزشکی اهواز Habib Heybar حبیب حی بر haidari58@gmail.com 100319475328460013848 100319475328460013848 No of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran دانشکده پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، ایران Bijan Helli بیژن حلی haidari58@gmail.com 100319475328460013849 100319475328460013849 No Department of Nutrition, School of Para-Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran گروه تغذیه، دانشکده پیراپزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز، ایران Majid Mohamadshahi مجید محمدشاهی shahi334@gmail.com 100319475328460013850 100319475328460013850 Yes Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran مرکز تحقیقات هایپرلیپیدمی، دانشگاه علوم پزشکی جندی شاپور اهواز، ایران