Journal of Babol University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی بابل
J Babol Univ Med Sci
Medical Sciences
http://jbums.org
1
admin
1561-4107
2251-7170
10.22088/jbums
fa
jalali
1385
1
1
gregorian
2006
4
1
8
2
online
1
fulltext
fa
بررسی ارزش تشخیصی AgNORs: Argyrophilic nucleolar organizer regions در تومورهای غدد بزاقی
Diagnostic value of Nucleolar organizer regions (NORs) in salivary gland tumors
بیوشیمی
Biochemical
تحلیلی
Research
.
BACKGROUND AND OBJECTIVE: Nowadays, besides the ordinary staining, a variety of cell markers and immunohistochemistry methods are incorporated for distinction between neoplasms. But in the current situation, due to the high cost of most of these methods, cheaper and simpler way like silver nitrate staining should be sought for analyzing the nucleolar organizer dots. Therefore, this study was conducted to evaluate the distinction capability of silver nitrate within the benign and malignant neoplasms of the salivary glands.<br>METHODS: Silver nitrate staining was carried out for nucleolar organizer regions in 22 cases of the most common benign neoplasms of the salivary glands, namely pleomorphic adenoma, and 22 cases of common malignant neoplasms of salivary glands, consisting of 11 adenoid cystic carcinoma and 11 mucoepidermoid carcinoma cases. Twenty-two cases of normal salivary glands of the peripheral regions of the same samples were analyzed.<br>FINDINGS: The mean dots occurrences for normal salivary glands, pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma were 1.67±0.2, 2.32±0.39, 3.92±1.11 and 3.25±0.78 (for malignancies was 3.58±1), respectively. There were significant differences among benign and malignant, malignant and normal, and benign and normal groups (p<0.05). <br>CONCLUSION: This study purposed that the use of silver nitrate staining method is suitable for distinction of the benign and malignant neoplasms of salivary glands.
پلئومورفیک آدنوما, آدنوئید سیستیک کارسینوما, موکواپی درموئید کارسینوما, غدد بزاقی, نقاط سازمان دهنده هسته ای
Pleomorphic adenoma, Adenoid cystic carcinoma, Mucoepidermoid carcinoma, Salivary glands, Nucleolar organizer regions
19
23
http://jbums.org/browse.php?a_code=A-10-1370-386&slc_lang=fa&sid=1
M
Seyed Majidi
مریم
سیدمجیدی،
10031947532846002768
10031947532846002768
Yes
M
Ali Zadeh
معصومه
علیزاده
10031947532846002769
10031947532846002769
No