TY - JOUR JF - Babol-Jbums JO - J Babol Univ Med Sci VL - 20 IS - 11 PY - 2018 Y1 - 2018/11/01 TI - Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures TT - اثرات ضدتشنجی هسپرتین در مدل حیوانی تشنج القا شده با پنتیلن تترازول N2 - Background and objective: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including anti-oxidant and anti-inflammatory effects. In this study, the effects of hesperetin on seizures behavior and its function on total antioxidant capacity and lipid peroxidation has been investigated in pentylenetetrazol (PTZ)-induced seizures model. Materials and methods: In this experimental study, thirty-five mice were divided into 5 experimental groups as control, saline and hesperetin at doses of 10, 20 or 50 mg/kg. Animals received orally the related interventions for 7 days. On day 7, 30 minutes after oral gavage, convulsion was induced by single intraperitoneal (i.p.) injection of PTZ at dose of 60 mg/kg. After recording of convulsion behaviors including latency to myoclonic jerks, latency and duration of generalized tonic-clonic seizures, time to death, measuring of Ferric Reducing Antioxidant Power (FRAP) and Thiobarbituric acid reactive substances (TBARS) carried out in hippocampus tissues. Findings: Pretreatment with hesperetin at dose of 50 mg/kg significantly increased the latency of myoclonic jerks (hesperetin 50: P=0.0323) and generalized tonic-clonic seizures (hesperetin 10: P= 0.0003, hesperetin 20: 0.0017, hesperetin 50: P=0.0040). Hesperetin application at dose of 10 mg/kg significantly reduced the levels of TBARS compared to control group. Any significant difference in FRAP levels was not observed between different experimental groups. Conclusion: The results of study indicate that hesperetin might be effective as supplementary treatment in epilepsy disorder. SP - 19 EP - 26 AU - Baradaran, S AU - Ghasemi-Kasman, M AU - Ebrahimpour, A AU - Ahmadian, SR AU - Pouramir, M AD - Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran KW - Hesperetin KW - Convulsion KW - Pentylenetetrazol UR - http://jbums.org/article-1-8073-en.html DO - 10.18869/acadpub.jbums.20.11.2 ER -