TY - JOUR T1 - Protective Effect of Bene (Pistacia Atlantica) on Busulfan-Induced Renal-Liver Injury in Laboratory Mice TT - اثر حفاظتی بنه کوهی بر آسیب کبدی و کلیوی القا شده با بوسولفان در موش آزمایشگاهی JF - Babol-Jbums JO - Babol-Jbums VL - 22 IS - 1 UR - http://jbums.org/article-1-8351-en.html Y1 - 2020 SP - 17 EP - 23 KW - Pistacia atlantica KW - wild pistacia KW - mouse KW - liver KW - kidney KW - busulfan. N2 - BACKGROUND AND OBJECTIVE: Busulfan is a chemotherapy drug that has side effects such as hepatic and renal injury. Pistacia atlantica from the family Anacardiaceae has a potent antioxidant agent due to phenolic compounds. The purpose of this study was to investigate the effects of Pistacia atlantica on histopathology and liver and kidney function indicators in busulfan-induced liver and kidney injuries in adult mice. METHODS: A total of 28 BALB/c mice were randomly divided into four groups (control, busulfan, bene and bene+busulfan). The busulfan group received 10 mg/kg busulfan as a single dose and intraperitoneally. The bene group received plate containing 10% of bene for 35 days. The bene+busulfan group received 10 mg/kg busulfan+10% bene. Then, liver enzymes alanine amino transferase, aspartate amino transferase, urea, creatinine and histopathology of liver and kidney investigated. FINDINGS: The mean urea (P= 0.009) and creatinine level (P= 0.02) in the busulfan group was 55.2±4.23 and 0.8±0.11 mg/dl that it was significantly higher than the bene + busulfan. A significant decrease in ALT level in the bene + busulfan group compared to the busulfan treated group (P= 0.03). In the bene treated group steatosis, necrosis and fibrosis in the liver parenchyma and glomerular sclerosis, inflammation and tubular atrophy in kidney tissue, was not observed. CONCLUSION: The results of present study indicated that administration of 10% bene for 35 days improved histopathology of kidney and liver as well as functional index of liver and kidney after renal-liver injury. M3 10.22088/jbums.22.1.17 ER -