TY - JOUR T1 - Effects of Sesame Oil on Improving Spatial Memory in Alzheimers Disease TT - تاثیر روغن کنجد(sesame oil) بر بهبود حافظه فضایی در بیماران آلزایمر JF - Babol-Jbums JO - Babol-Jbums VL - 16 IS - 2 UR - http://jbums.org/article-1-4642-en.html Y1 - 2014 SP - 34 EP - 41 KW - Alzheimer KW - Sesame Oil KW - Spatial memory. N2 - BACKGROUND AND OBJECTIVE: Alzheimers disease is the most common neurodegenerative diseases. According to the positive effects of unsaturated fatty acids of sesame oil on neurons membrane and causing defense against free radicals, the aim of this study was to investigate the reinforcing effects of sesame oil on spatial memory in Alzheimers rat. METHODS: In this experimental study, 35 male rats weighing approximately 200±50 gram were divided in five equal groups: control, sham (salin recipient), Alzheimers model (ICV injection of streptozotocin) and 2 groups of Alzheimers model + sesame oil pretreatment (8 and 5 ml/kg by IP for 28days). Alzheimers model was induced by ICV injection of streptozotocin (1.5 mg/kg). The Morris Water maze was used for studying the spatial learning memory.FINDINGS: Intraventricular injection of streptozotocin damaged the spatial memory. Pretreatment of sesame oil (5 and 8 ml/kg 28 days by ip injection) significantly (p M3 10.18869/acadpub.jbums.16.2.34 ER -