|
Evaluation of Glucagon-Like Peptide 1 (GLP-1) Levels and Oxidative Stress in Preterm Infants
|
E Abbasi *    , F Pishbin , N Tahmasebpour Shahsavar , R Shahabi , ME Ghafari , S Tabatabai , S Heidari |
| 1.Department of Clinical Biochemistry, School of Medicine, HamadanUniversity of Medical Sciences, Hamadan, I.R.Iran. , 7abbasi@gmail.com |
|
|
Abstract: (2967 Views) |
Background and Objective: Glucagon-like peptide 1 (GLP-1) has anti-diabetic, antioxidant and anti-inflammatory properties that change under different conditions. This peptide is known as a therapeutic target in diabetes and obesity. The aim of this study was to investigate the relationship between GLP-1 and oxidative stress in preterm infants.
Methods: In this case-control study, 40 term and preterm infants (gestational age less than 37 weeks) were used. GLP-1 concentration was measured by ELISA. Total antioxidant capacity (TAC), total oxidant status (TOS) and uric acid concentration were measured.
Findings: Serum GLP-1 level in preterm infants was significantly higher than term infants (p=0.003). Serum TAC level in preterm infants (973.16±235.53) was significantly lower than term infants (837.00±218.97) (p=0.006). Serum TOS level in preterm infants (65.46±33.52) was significantly higher than term infants (31.50±14.62) (p<0.001). Uric acid levels in preterm infants (5.83±1.73) were statistically higher than term infants (5.13±0.90) (p=0.02). Serum GLP-1 level in preterm infants was negatively and significantly correlated with TAC (p<0.001, r=-0.674) and positively and significantly correlated with TOS (p<0.001, r=0.754) and uric acid (p<0.001, r=0.633).
Conclusion: The results showed that the levels of GLP-1, TOS and uric acid in preterm infants were higher than term infants and GLP-1 had a negative correlation with TAC capacity and a positive correlation with TOS and uric acid in these infants. |
|
| Keywords: Infant, Glucagon-Like Peptide 1 (GLP-1), Oxidative Stress, Uric Acid. |
|
|
Full-Text [PDF 312 kb]
(670 Downloads)
|
Type of Study: Case-Control |
Subject:
Biochemical
Received: 2021/02/13 | Accepted: 2021/07/11 | Published: 2022/01/10
|
|
|
|
|
|
