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Experimental Models of Thrombocytopenia in Laboratory Animals and Their Application in Side Effect Recognition of Cancer Chemotherapy Drugs
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| H Kamali , MR Khazaei , E Shobeiri , M Khazaei * |
| Kermanshah University of Medical Sciences , mkhazaei1345@yahoo.com |
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Abstract: (288 Views) |
Background and Objective: Thrombocytopenia is one of chemotherapy drug side effect which resulte in death in acute condition. Various animal models of thrombocytopenia were used for clinical research on recognition different inducing and inhibiting factors. The aim of present review study was to investigate thrombocytopenia inducing models in laboratory animals and their benefits and defects.
Methods: In this systematic review, keywords: thrombocytopenia, platelets, chemotherapy, animal models were searched in the databases: Pubmed, Science Direct, Elsevier. Many articles were found and after evaluation the titles and abstract, unrelated articles were eliminated and final articles were selected and were investigated.
Results: Animal models of thrombocytopenia are divided into immune and non-immune models. Non-immune models involve in bone marrow suppression and decreased production of platelets. Immune models encompass the usage of anti-platelet antibodies that leads to distraction of platelet. Regarding to the various diseases leading to thrombocytopenia and limitation of human experimental research, Animal thrombocytopenia models are required to study and recognize the effective causes of disease.
Conclusion: The immune and non-immune thrombocytopenia models have benefits and limitation and were selected based on research goals. Laboratory animals always were mice and the most inducer drug was cyclophosphamide and carboplatin.
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| Keywords: Thrombocytopenia, platelets, chemotherapy, Animal models. |
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Type of Study: Review |
Subject:
pharmacology
Received: 2017/10/13 | Accepted: 2018/03/4 | Published: 2018/03/17
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