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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 20, Issue 2 (2-2018) ::
J Babol Univ Med Sci. 2018; Volume 20 Back to browse issues page
A Comparison of the Effect of Ondansetron and Propofol on Intrathecal Opioid-Induced itch in Elective Cesarean Section
A Mahouri , Sh Sane * , E Hassani , H Rezaie , L Aghasi
Department of Anesthesiology and Critical Care, Urmia University of Medical Sciences, Urmia, I.R.Iran , shahryarsane@yahoo.com
Abstract:   (4989 Views)

BACKGROUND AND OBJECTIVE: Itch is one of the most common and uncomfortable side effects of neuraxial anesthesia. Its incidence is higher especially in cesarean section. The aim of this study was to compare the effect of ondansetron and propofol at doses lower than the hypnotic dose on the treatment of itch induced by intrathecal fentanyl in cesarean section.
METHODS: In this prospective study, 90 patients with American Society of Anesthesiologists (ASA) class I and class II with an average age of 30 years and first time cesarean section underwent intra-spinal anesthesia with 25 μg fentanyl and 10 mg bupivacaine 0.5%. Women were randomly divided into two groups of 45. One group received 4 mg ondansetron and another group received 10 mg propofol at first and then 10 μg / kg / min through infusion. The incidence and severity of itch were recorded on the basis of the visual scoring system during operation and during recovery.
FINDINGS:The highest incidence of itch was 30 to 60 minutes after injection. The incidence of itch during surgery was 2.22% and 7.26%, and during recovery was 7.6% and 8.8%, in the ondansetron and propofol groups, respectively (p=0.5, p=0.4). The mean itch severity scores during surgery were 1.85±0.69 and 1.66±0.81, and during the recovery were 1.33±0.57 and 1.25±0.5, in the ondansetron and propofol groups, respectively (p=0.65) (p=0.84).
CONCLUSION: Based on the results of this study, ondansetron and propofol at doses lower than the hypnotic dose were well tolerated. Considering the effect of both drugs on the treatment of itch caused by intrathecal fentanyl, both of them can be used clinically.

 

Keywords: Itch, Ondansetron, Propofol, Opiate, Caesarean section.
Full-Text [PDF 191 kb]   (1638 Downloads)    
Type of Study: Experimental | Subject: Anesthesia
Received: 2017/06/12 | Accepted: 2018/01/15 | Published: 2018/01/24
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Mahouri A, Sane S, Hassani E, Rezaie H, Aghasi L. A Comparison of the Effect of Ondansetron and Propofol on Intrathecal Opioid-Induced itch in Elective Cesarean Section. J Babol Univ Med Sci 2018; 20 (2) :7-12
URL: http://jbums.org/article-1-6882-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 20, Issue 2 (2-2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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