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:: Volume 19, Issue 12 (12-2017) ::
JBUMS 2017, 19(12): 0-0 Back to browse issues page
Evaluation of Changes in Liver Function Tests in Very Young Infants under Intravenous Feeding
S Aramli , H Yaghoubi *, J Khalafi , S Shahizadeh
Assistant Professor Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran , yaghoubi_h@iauardabil.ac.ir
Abstract:   (248 Views)

A premature infant is a baby born before 37 completed weeks of gestation (more than 3 weeks before the due date). Extrauterine growth restriction is a major clinical problem in preterm infants.  In this regards, total parenteral nutrition (TPN) is the intravenous infusion of all nutrients necessary for metabolic requirements and growth in premature infants. The aim of this study was to determine whether TPN affect blood biochemical markers in the preterm infant



METHODS: This study an observation, description and sectional study with IR-ARUMS-REC-1394-109 moral code was performed from November of 2015 to December of 2016 in Alavi Hospital with 26 samples. Twenty-six preterm infants with gestational age 27 to 33 weeks and birth weight 800 to 1900 g  who were placed on TPN regimens are included within this study. Blood variables including Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Gamma-glutamyl transferase (GGT), and Total bilirubin (T-Bill), Direct bilirubin (D-Bill) were measured.
FINDINGS: According to our results, ALP and GGT levels shown a significant increasing (P<0.05) after receiving TPN, while, T-Bil and D-Bil levels were significantly lower after receiving TPN (P<0.05). However, there were no significant differences in AST and ALT levels before and after TPN regime (P>0.05).


CONCLUSION: None of newborns were diagnosed with cholestasis. Despite previous studies, this study concluded there was no cause cholestasis by parenteral nutrition. 
Given the natural history of neonatal total bilirubin decreased significantly. Alp,GGT,Bill D in numerical statistically significant increase but they were in referance range after total parentral nutrition.  
Keywords: Liver Enzymes, Total parenteral nutrition (TPN), Premature Infant
     
Type of Study: Case-Control | Subject: Biochemical
Received: 2017/05/25 | Accepted: 2017/11/6 | Published: 2017/11/14
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Aramli S, Yaghoubi H, Khalafi J, Shahizadeh S. Evaluation of Changes in Liver Function Tests in Very Young Infants under Intravenous Feeding. JBUMS. 2017; 19 (12)
URL: http://jbums.org/article-1-6840-en.html
Volume 19, Issue 12 (12-2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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