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:: Volume 18, Issue 5 (5-2016) ::
JBUMS 2016, 18(5): 31-37 Back to browse issues page
The Analgesic Effect of Echinophora Platyloba Hydroalcoholic Extract in Male Rats
M Asgari Nematian , S Mohammadi
Department of Biology, Hamedan Branch, Islamic Azad University, Hamedan, I.R.Iran , smiauhphd.sm@gmail.com
Abstract:   (3990 Views)

BACKGROUND AND OBJECTIVES: In traditional Iranian medicine, use of medicinal herbs is prevalent for the treatment and alleviation of pain and inflammation. Echinophora Platyloba is one of the major medicinal herbs with confirmed anti-cancer, anti-microbial, and anti-fungal effects. Therefore, in this study, we aimed to evaluate the analgesic effects of E. platyloba hydroalcoholic extracts in male rats.

METHODS: In this experimental study, 42 rats were divided into six groups, i.e., control group, extract groups (80, 100, and 300 mg/kg via intraperitoneal injection), morphine group (1 mg/kg via intraperitoneal injection), and naloxone group (1 mg/kg of naloxone along with 300 mg/kg of the extract). To evaluate the analgesic effects of the extracts, rating, tail flick, and formalin tests were performed.

FINDINGS: In the writhing test, doses of 100 and 300 mg/kg of the extracts could decrease the rating score from 43.3±22.61 to 27.31±2.34 (p<0.05) and 29.0±67.91 (p<0.01) in the control group, respectively. In addition, administration of 300 mg/kg of the extract in tail flick test decreased the latency time from 2.84±0.76 to 5.52±1.88 sec in the control group (p<0.05). Moreover, in formalin test, 300 mg/kg of the extract reduced the pain score in both acute and chronic phases from 2.18±0.22 to 0.74±0.13 in the control group (p<0.01).

CONCLUSION: According to the present results, E. platyloba hydroalcoholic extracts have central and peripheral analgesic effects.

Keywords: Hydroalcoholic Extract, Analgesic, Echinophora Platyloba, Medicinal Herbs
Full-Text [PDF 250 kb]   (1140 Downloads)    
Type of Study: Experimental | Subject: pharmacology
Received: 2015/11/1 | Accepted: 2016/04/6 | Published: 2016/05/1
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Asgari Nematian M, Mohammadi S. The Analgesic Effect of Echinophora Platyloba Hydroalcoholic Extract in Male Rats. JBUMS. 2016; 18 (5) :31-37
URL: http://jbums.org/article-1-5795-en.html

Volume 18, Issue 5 (5-2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

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