:: Volume 18, Issue 11 (11-2016) ::
J Babol Univ Med Sci. 2016; Volume 18 Back to browse issues page
The Effect of Colchicine in Improving the Symptoms of Patients with Knee Osteoarthritis
A Amirpour , MA Mousavi * , R Abolghasemi , O Taziki , HR Khoddami Vishteh
Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, I.R.Iran , seyedeh.maryam.mousavi@gmail.com
Abstract:   (5535 Views)

BACKGROUND AND OBJECTIVE: Due to low effectiveness of drugs in osteoarthritis treatment, finding new drugs always consider. Although colchicine has been described as a disease moderator medicine for osteoarthritis disease or symptoms, few studies have been carried out about the effect of it in soothing symptoms of patients with knee osteoarthritis.

METHODS: This RCT was conducted on 62 patients with idiopathic knee osteoarthritis. Pain intensity, the degree of functional disability, and the patients’ clinical health were assessed by VAS, modified WOMAC index and modified HAQ questionnaire, respectively. The patients were then randomly assigned to two groups of oral colchicine group (0.5mg/bid) and placebo group and undergone treatment for 4 months. Assessment repeated in 3rd and 4th months. IRCT code: IRCT2015071623240N1.

FINDINGS: Compared to the beginning of the study, the intensity of pain in both groups was reduced and the degree of functional disability and the patients’ clinical health were improved in the 3rd and 4th months of study, too. Nevertheless, the percentages of pain severity improvement in colchicine group in comparison to placebo were significantly higher (3rd mo: 29% vs. 16%, respectively, p=0.030; 4th mo: 37% vs. 20%, respectively, p=0.014). In addition, the percentages of physical function improvement in colchicine group in comparison to placebo were significantly higher (3rd mo: 26% vs. 16%, respectively, p=0.048; 4th mo: 28% vs. 20%, respectively, p=0.036).

CONCLUSION: Use of colchicine for four months in patients with knee osteoarthritis can reduce pain and improve physical function.

Keywords: Knee Osteoarthritis, Colchicine, Placebo
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Type of Study: Interventional | Subject: Internal (Rheumatology)
Received: 2015/10/11 | Accepted: 2016/02/20 | Published: 2016/12/27

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Volume 18, Issue 11 (11-2016) Back to browse issues page