Comparison of Efficacy of Transdermal Fentanyl Patch and Intravenous Morphine on Postoperative Pain of Esophageal Cancer Surgery with Trans-Hiatal Approach
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P. Amri Maleh (MD) , E. Alijanpour (MD) , N. Nikbakhsh (MD) * , N. Samarghandi (MD) , M. Esmaeilnia (MD) , S. Khafri (PhD) |
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Abstract: (7818 Views) |
BACKGROUND AND
OBJECTIVE: Effective control of postoperative
pain is very important to reduce its complications. This study was
performed to compare the efficacy of trans-dermal fentanyl patch and
intravenous morphine on postoperative pain of esophageal cancer surgery with
trans-hiatal approach. METHODS: In
this double blind clinical trial study, 57 ASA class I-II patients who
scheduled for elective esophageal cancer surgery with trans-hiatal approach were randomly divided into two groups (M=Morphine,
F=Fentanyl patch). In a fentanyl group (F), a TFP (50 µg/h) was placed on
chest wall skin one hour before the induction of anesthesia. In M group,
morphine 4 mg was administrated at the end of surgery. Pain score, blood pressure, heart rate and respiratory
rate in 0-2-4-6 and then every 6 hours for 72 hours after surgery were
measured. In both groups 4mg intravenous morphine
was administered to the patient if they had pain score (base of visual analogue
scale) more than three. Finally, the mean amount of morphine, pain
score, the incidence of respiratory depression,
changes in blood pressure and heart rate in two groups was compared.
(IRCT:201110107752N1) FINDINGS: The numbers of
patients in fentanyl and morphine groups were 29 and 28,
respectively. The two groups were similar for age, gender and weight. The
efficacy of TFP to reduce pain score after operation was better than the
Morphine group (p<0.001). The mean amount of prescribed morphine in M group
was (64±3.82mg) and in F group (20±5.63mg)
(p<0.05). The incidence of respiratory depression, blood pressure and heart
rate variation was not significant in two groups. CONCLUSION: This study showed that the transdermal fentanyl
patch (TFP) could be an appropriate and effective method to reduce postoperative
pain of esophageal cancer surgery with trans-hiatal approach. |
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Keywords: Transdermal fentanyl patch, Morphine, Esophagus cancer, Visual analogue scale. |
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Full-Text [PDF 475 kb]
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Type of Study: Research |
Subject:
Histology Received: 2014/02/15 | Accepted: 2014/06/25 | Published: 2014/08/26
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