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:: Volume 16, Issue 4 (4-2014) ::
J Babol Univ Med Sci. 2014; Volume 16 Back to browse issues page
Anti-Inflammation Effect of Alcoholic Extract of Linum
S . Ebrahimi Vosta Kalaee * , A Talebi Mazraeh Shahi , M Naseri
Abstract:   (8756 Views)
BACKGROUND AND OBJECTIVE: The anti-inflammatory drugs are associated with the wide side effect. The herbal medicine has fewer side effects. Numerous references to anti-inflammatory effects of Linum usitatissimum L. have been noted in our traditional medicine. In the present study, anti-inflammatory effects of flaxseed extract has been studied and with anti-inflammatory effects of sodium salicylate was compared. METHODS: In this experimental study 90 male albino rats (weighing 200‐300 gr) were used. Animals were randomly divided into 15 groups (n=6): positive control (sodium salicylate 200 mg/kg i.p.), negative control (DMSO 10%, 10 ml/kg i.p.) and treatment groups received extract (100, 200,400 mg/kg i.p.) in a similar volume. Flaxseed hydroalcholic extract was prepared by maceration. Half an hour after, inflammation was induced by injection (s.c.) 0.1 ml Carrageenan (1% w/v in saline solution) into the hind paw or 0.03 ml xylene behind the ear and or 1 ml ovalbumin (2%) into the hind paw. The paw volume was measured with plethysmometer in 1, 2, and 3 h after the carrageenan (or ovalbumin) injection. In xylene test, 0.03 ml of xylene was injected to the posterior surfaces of the right ear and the weight of two ears after 2 h was also compared. FINDINGS: The results showed that all doses of Flaxseed hydroalcoholic extract in dose-dependent manner significantly reduced inflammation in both acute and chronic phases in compared with the negative control group (p<0.05, p<0.01). The extract (400 mg/kg) reduced inflammation in Carrageenan test 56%, the albumin 69%, and xylene 60% when compared with anti-inflammatory effects of sodium Salyslat (50%). CONCLUSION: The results of this study showed that flaxseed extract has significant anti-inflammatory effects but to understand the possible mechanism of this effect, additional research is needed.
Keywords: Flaxseed, Carrageenan, Xylene, Ovalbumin, Rat
Full-Text [PDF 1106 kb]   (2051 Downloads)    
Type of Study: Research | Subject: Biochemical
Received: 2014/04/5 | Accepted: 2014/04/5 | Published: 2014/04/5



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. Ebrahimi Vosta Kalaee S, Talebi Mazraeh Shahi A, Naseri M. Anti-Inflammation Effect of Alcoholic Extract of Linum . J Babol Univ Med Sci 2014; 16 (4) :50-56
URL: http://jbums.org/article-1-4676-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 4 (4-2014) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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