[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Ethics::
peer-review::
Indexing::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal DOI

AWT IMAGE

..
Copyright Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
This Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0
..
:: Volume 13, Issue 6 (11-2011) ::
J Babol Univ Med Sci. 2011; Volume 13 Back to browse issues page
Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction
M Hashemian, * , AR Vakili, , A Akaberi
Abstract:   (8895 Views)
BACKGROUND AND OBJECTIVE: According to high prevalence and mortality of ischemic heart disease, mention to treatment is important. Glucose–insulin–potassium (GIK) as an adjunctive treatment of ST segment elevation myocardial infarction (STEMI) has been suggested but its effects are controversial. Whereas C-reactive protein (CRP) has prognostic value, we aimed to evaluate the effect of GIK on Plasma concentrations of C-reactive protein in STEMI patients.
METHODS: This randomized clinical trial enrolled 72 patients who had STEMI that were referred to Vaseie hospital of Sabzevar, Iran. Patients were categorized to two groups by block randomization and were treated with a high dose of GIK (25% glucose, 50 IU of soluble insulin per liter, and 80 m mol of potassium chloride per liter at 1 ml/kg/hour) (GIK group) or normal saline (control group) as adjunct to thrombolytic therapy. We analyzed Plasma concentrations of high-sensitivity C-reactive protein (CRP) at baseline and sequentially for 48 hours.
FINDINGS: Baseline CRP)GIK=5.6±5.9,control=4.0±4.3mg/L, p=0.35 (were significantly increased to 3-fold at 48 hours in each group (GIK=16.8±2.2, control=15.5±3.2mg/L, p=0.17). There was no difference in plasma concentrations of CRP between GIK and control patients (p=0.24). Mean glucose level over 6 hours was higher in GIK group (212±13 mg/dL) than control group (142±46 mg/dL, p=0.006).
CONCLUSION: In patients with acute myocardial infarction treated with streptokinase, glucose-insulin-potassium therapy offers no anti-inflammatory effect.
Keywords: Glucose, Insulin, Potassium, Myocardial infarction, C-reactive protein
Full-Text [PDF 271 kb]   (1364 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/8 | Published: 2014/06/8


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hashemian, M, Vakili, A, Akaberi A. Effect of Glucose–Insulin–Potassium on Plasma Concentrations of C - Reactive Protein in Acute Myocardial Infarction. J Babol Univ Med Sci 2011; 13 (6) :45-51
URL: http://jbums.org/article-1-3924-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 6 (11-2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Persian site map - English site map - Created in 0.05 seconds with 43 queries by YEKTAWEB 4645