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:: Volume 11, Issue 6 (1-2010) ::
J Babol Univ Med Sci. 2010; Volume 11 Back to browse issues page
Prevalence of Celiac Disease in Type 1 Diabetic Children and adolescents in East Azarbaijan
R Ghergherehchi, * , M Rafeey , J Majidi , S Majidi
Abstract:   (6820 Views)
BACKGROUND AND OBJECTIVE: Celiac disease (CD) is a chronic enteropathy caused by hypersensitivity to gluten. Most studies have shown more prevalence of CD in the patients with diabetes mellitus type 1 (DM1). The prevalence of CD among DM1 children is unknown. The aim of this study is to survey the prevalence of celiac disease in type 1 diabetic children in East Azarbaijan.
METHODS: In a cross-sectional study, 135 children with diabetes mellitus type 1 referring to Tabriz children hospital endocrine department and clinic from 2006 to 2008 were selected. The serumic level of A-tTG-A-IgA and AEA-IgA were measured by ELISA method and serum IgA level was measured by nephelometry for screening of celiac disease. In the case that A-tTG-A either AEA was high, distal duodenal biopsy was preformed.
FINDINGS: Twenty eight of 135 patients with diabetes mellitus type 1, were serologically positive for celiac. Four of 28 (14.28%) seropositive paitients were A-tTG-A positive, ten (35.71%) of them were AEA positive and fourteen (50%) were A-tTG-A and AEA positive. Confirmed celiac prevalence based on biopsy was 6.8%.
CONCLUSION: Celiac disease in diabetic patients (DM1) is common. Screening of celiac disease with serologic tests in diabetic patients is necessary for the purpose of early diagnosis and prevention from severe complications of celiac disease.
Keywords: Diabetes melliuts, Type 1, Celiac disease
Full-Text [PDF 782 kb]   (1761 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/5 | Published: 2014/06/5


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Ghergherehchi, R, Rafeey M, Majidi J, Majidi S. Prevalence of Celiac Disease in Type 1 Diabetic Children and adolescents in East Azarbaijan. J Babol Univ Med Sci 2010; 11 (6) :40-45
URL: http://jbums.org/article-1-3372-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 6 (1-2010) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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