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:: Volume 10, Issue 3 (8-2008) ::
J Babol Univ Med Sci. 2008; Volume 10 Back to browse issues page
EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT
MA Allahtavakoli * , A Shamsizadeh , M Mahmoodi, , R Moloudi, , ME Rezvani
Abstract:   (7471 Views)
BACKGROUND AND OBJECTIVE: Stroke is one of the leading causes of death and disability in the world. Previous studies have demonstrated that α-tocotrienol (α-TCT) and rosiglitazone (RGZ) reduce ischemic damage by middle cerebral artery (MCA) occlusion when administered before ischemic stroke in mice and rats. The aim of this study was to investigate the neuroprotective effects of α-TCT and RGZ at 3 hours after cerebral ischemia.
METHODS: In this experimental study, stroke was induced by embolizing a preformed clot into the MCA. Male Wistar rats (300-350 gr) were assigned to α-TCT (1 or 10 mg/kg), rosiglitazone (RGZ) and sham-operation. The drugs were injected i.p. Stained brain sections were scanned and infarct area were determined using a picture analyzer software.
FINDINGS: Forty eight hours after embolic ischemia, infarct volume in the control, RGZ, low and high doses of α-TCT were 29.4±2.6%, 15.9±3.1%, 24.9±2.1% and 29±4.8%, respectively. There was a significant difference between control and RGZ groups (p<0.05). Compared to the control group, the low and high doses of α-TCT didn’t show any significant difference. Furthermore, only RGZ decreased neurological deficits (p<0.05) and sensory impairments (p<0.01).
CONCLUSION: Administration of α-TCT at 3 hr after induction of cerebral ischemia is not neuroprotective but RGZ may have beneficial effects on treatment and management of stroke. So further studies are needed to survey the neuroprotective effects of α-TCT after stroke.
Keywords: Cerebral ischemia, Embolic model, α-tocotrienol, Vitamin E, Neuroprotection
Full-Text [PDF 429 kb]   (1635 Downloads)    
Type of Study: Research | Subject: Biochemical
Accepted: 2014/06/3 | Published: 2014/06/3


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Allahtavakoli M, Shamsizadeh A, Mahmoodi, M, Moloudi, R, Rezvani M. EFFECT OF α-TOCOTRIENOL AND PROXISOME PROLIFRATIVE-ACTIVATED RECEPTOR LIGAND ON THE BRAIN ISCHEMIA IN MALE RAT. J Babol Univ Med Sci 2008; 10 (3) :7-14
URL: http://jbums.org/article-1-2465-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 3 (8-2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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