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This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 
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:: Volume 22, Issue 1 (3-2020) ::
J Babol Univ Med Sci. 2020; Volume 22 Back to browse issues page
Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
S Gholamian , SR Attarzadeh Hoseini * , A Rashidlamir , H Aghaalinejad
1.Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, I.R.Iran , attarzadeh@um.ac.ir
Abstract:   (3879 Views)
BACKGROUND AND OBJECTIVE: Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence aerobic interval training on expression of mesenchymal biomarkers, and tumor volume in mice with breast cancer.
METHODS: In this experimental study, Thirty-two female BALB/c mice, aged 3-5 weeks (17±1g) were used. The mice were allocated to four groups: Exercise Tumor, Exercise (aerobic Interval training was performed six weeks (40 minutes) before and four weeks (30 minutes) after the induction of carcinoma with active recovery), Rest Tumor, Rest (Control- without exercise), Rest, Tumor, Exercise, (four weeks after the induction of carcinoma) and Exercise, Tumor, Rest (six weeks before the induction of carcinoma). The real-time PCR method was used to evaluate the expression of Vimentin and Twist.
FINDINGS: The results of present study demonstrated that tumor tissue Vimentin expression in the Exercise Tumor Exercise (223.0±0.073) group decreased significantly (p= 0.0001), Also, the expression of Twist gene was significantly reduced in Exercise Tumor Exercise group (0.24±0.227) compared to control group (p=0.008). A significant decrease in tumor volume was observed in both RTE and ETE groups compared to the control group (RTR) (p = 0.0001).
CONCLUSION: Based on the results of this study, a period of interval aerobic training can decrease the expression of Vimentin، Twist and decrease the tumor volume ratio.
Keywords: Breast cancer, Mesenchymal biomarkers, Interval training, Tumor.
Full-Text [PDF 381 kb]   (1944 Downloads)    
Type of Study: Quasi Experimental | Subject: Sport Physiology
Received: 2019/01/20 | Accepted: 2019/07/1 | Published: 2019/12/25
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Gholamian S, Attarzadeh Hoseini S, Rashidlamir A, Aghaalinejad H. Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer. J Babol Univ Med Sci 2020; 22 (1) :24-30
URL: http://jbums.org/article-1-8470-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 22, Issue 1 (3-2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی بابل Journal of Babol University of Medical Sciences

The Journal of Babol University of Medical Sciences is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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